Literature DB >> 8540892

Childhood hyperactivity scores are highly heritable and show sibling competition effects: twin study evidence.

A Thapar1, A Hervas, P McGuffin.   

Abstract

Hyperactivity has consistently been shown to be familial. Until recently however, due to a lack of systematic twin evidence, it has remained uncertain to what extent familial transmission can be explained by genetic factors. We used a systematically ascertained population-based sample of twin pairs aged between 8 and 16 years old to explore the role of genetic influences on maternally rated hyperactivity scores. Hyperactivity scores were found to be substantially heritable. The data were best explained by a model which incorporated sibling competitive effects as well as additive genetic factors. These findings suggest not only that hyperactivity scores are influenced by genetic factors but that sibling interaction effects are also of importance.

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Year:  1995        PMID: 8540892     DOI: 10.1007/bf02327577

Source DB:  PubMed          Journal:  Behav Genet        ISSN: 0001-8244            Impact factor:   2.805


  29 in total

1.  Pre- and perinatal factors and the risk of subsequent referral for hyperactivity.

Authors:  C A Chandola; M R Robling; T J Peters; G Melville-Thomas; P McGuffin
Journal:  J Child Psychol Psychiatry       Date:  1992-09       Impact factor: 8.982

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3.  Genetics of Type A behavior in two European countries: evidence for sibling interaction.

Authors:  J Sims; D I Boomsma; D Carroll; J K Hewitt; J R Turner
Journal:  Behav Genet       Date:  1991-09       Impact factor: 2.805

4.  Sibling imitation and contrast effects.

Authors:  G Carey
Journal:  Behav Genet       Date:  1986-05       Impact factor: 2.805

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Authors:  D J Safer
Journal:  Behav Genet       Date:  1973-06       Impact factor: 2.805

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Journal:  Arch Gen Psychiatry       Date:  1972-09

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Authors:  R Schachar; M Rutter; A Smith
Journal:  J Child Psychol Psychiatry       Date:  1981-10       Impact factor: 8.982

9.  Perinatal complications and clinical outcome within the schizophrenia spectrum.

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Journal:  Br J Psychiatry       Date:  1982-04       Impact factor: 9.319

10.  Are anxiety symptoms in childhood heritable?

Authors:  A Thapar; P McGuffin
Journal:  J Child Psychol Psychiatry       Date:  1995-03       Impact factor: 8.982

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  22 in total

Review 1.  Hyperactivity in children: a focus on genetic research and psychological theories.

Authors:  J Kuntsi; J Stevenson
Journal:  Clin Child Fam Psychol Rev       Date:  2000-03

2.  Etiology of inattention and hyperactivity/impulsivity in a community sample of twins with learning difficulties.

Authors:  E G Willcutt; B F Pennington; J C DeFries
Journal:  J Abnorm Child Psychol       Date:  2000-04

3.  The etiology of behavior problems in 7-year-old twins: substantial genetic influence and negligible shared environmental influence for parent ratings and ratings by same and different teachers.

Authors:  Kimberly J Saudino; Angelica Ronald; Robert Plomin
Journal:  J Abnorm Child Psychol       Date:  2005-02

4.  BEHAVIORAL GENETICS: THE SCIENCE OF ANTISOCIAL BEHAVIOR.

Authors:  Laura A Baker; Serena Bezdjian; Adrian Raine
Journal:  Law Contemp Probl       Date:  2006

Review 5.  Phenotypic and measurement influences on heritability estimates in childhood ADHD.

Authors:  Christine M Freitag; Luis A Rohde; Thomas Lempp; Marcel Romanos
Journal:  Eur Child Adolesc Psychiatry       Date:  2010-03-07       Impact factor: 4.785

Review 6.  Understanding the complex etiologies of developmental disorders: behavioral and molecular genetic approaches.

Authors:  Erik G Willcutt; Bruce F Pennington; Laramie Duncan; Shelley D Smith; Janice M Keenan; Sally Wadsworth; John C Defries; Richard K Olson
Journal:  J Dev Behav Pediatr       Date:  2010-09       Impact factor: 2.225

7.  Phenotypic subtypes in attention deficit hyperactivity disorder in an isolated population.

Authors:  Esther A Croes; Rachid El Galta; Jeanine J Houwing-Duistermaat; Robert F Ferdinand; Sandra López León; Tessa A M Rademaker; Marieke C J Dekker; Ben A Oostra; Frank Verhulst; Cornelia M Van Duijn
Journal:  Eur J Epidemiol       Date:  2005       Impact factor: 8.082

8.  European clinical guidelines for hyperkinetic disorder -- first upgrade.

Authors:  Eric Taylor; Manfred Döpfner; Joseph Sergeant; Philip Asherson; Tobias Banaschewski; Jan Buitelaar; David Coghill; Marina Danckaerts; Aribert Rothenberger; Edmund Sonuga-Barke; Hans-Christoph Steinhausen; Alessandro Zuddas
Journal:  Eur Child Adolesc Psychiatry       Date:  2004       Impact factor: 4.785

9.  Personality traits among ADHD adults: implications of late-onset and subthreshold diagnoses.

Authors:  S V Faraone; A Kunwar; J Adamson; J Biederman
Journal:  Psychol Med       Date:  2008-06-30       Impact factor: 7.723

10.  Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity.

Authors:  I D Waldman; D C Rowe; A Abramowitz; S T Kozel; J H Mohr; S L Sherman; H H Cleveland; M L Sanders; J M Gard; C Stever
Journal:  Am J Hum Genet       Date:  1998-12       Impact factor: 11.025

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