Literature DB >> 8540726

In vitro activity of levofloxacin, singly and in combination with rifamycin analogs, against Mycobacterium leprae.

A M Dhople1, M A Ibanez.   

Abstract

The in vitro susceptibility of Mycobacterium leprae to levofloxacin was studied by using two biochemical parameters to measure the metabolic activity of the organism. Levofloxacin consistently exhibited twofold greater bactericidal activity than ofloxacin, with the MIC being 0.75 microgram/ml. When combined with one of the three rifamycin analogs, synergism was obtained with KRM-1648 and rifabutin but not with rifampin.

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Year:  1995        PMID： 8540726      PMCID： PMC162891          DOI： 10.1128/AAC.39.9.2116

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Clinical trial of pefloxacin and ofloxacin in the treatment of lepromatous leprosy.

Authors:  J H Grosset; B H Ji; C C Guelpa-Lauras; E G Perani; L N N'Deli
Journal:  Int J Lepr Other Mycobact Dis       Date:  1990-06

2.  In vitro growth of Mycobacterium lepraemurium, an obligate intracellular microbe.

Authors:  A M Dhople; J H Hanks
Journal:  Science       Date:  1977-07-22       Impact factor: 47.728

3.  Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method.

Authors:  H O Hallander; K Dornbusch; L Gezelius; K Jacobson; I Karlsson
Journal:  Antimicrob Agents Chemother       Date:  1982-11       Impact factor: 5.191

4.  Activity of ofloxacin against Mycobacterium leprae in the mouse.

Authors:  J H Grosset; C C Guelpa-Lauras; E G Perani; C Beoletto
Journal:  Int J Lepr Other Mycobact Dis       Date:  1988-06

5.  Activity of ciprofloxacin and other fluorinated quinolones against mycobacteria.

Authors:  L S Young; O G Berlin; C B Inderlied
Journal:  Am J Med       Date:  1987-04-27       Impact factor: 4.965

6.  Limited in vitro multiplication of Mycobacterium leprae.

Authors:  A M Dhople; K J Green; L J Osborne
Journal:  Ann Inst Pasteur Microbiol       Date:  1988 Mar-Apr

7.  Bacteriostatic and bactericidal activity of ciprofloxacin and ofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex.

Authors:  L B Heifets; P J Lindholm-Levy
Journal:  Tubercle       Date:  1987-12

8.  Evaluation of a bioluminescence assay for rapid antimicrobial susceptibility testing of mycobacteria.

Authors:  B Beckers; H R Lang; D Schimke; A Lammers
Journal:  Eur J Clin Microbiol       Date:  1985-12       Impact factor: 3.267

9.  The in-vitro activities of novel benzoxazinorifamycins against Mycobacterium leprae.

Authors:  A M Dhople; M A Ibanez
Journal:  J Antimicrob Chemother       Date:  1995-04       Impact factor: 5.790

10.  In vitro antituberculosis activity of a new antibacterial substance ofloxacin (DL8280).

Authors:  M Tsukamura
Journal:  Am Rev Respir Dis       Date:  1985-03
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  3 in total

1.  Tuberculosis treatment unmasking leprosy: management of drug-resistant tuberculosis and leprosy co-infection.

Authors:  G Kama; G K L Huang; M Taune; R Arura; L Morris; B Kombuk; A Marome; D P O'Brien
Journal:  Public Health Action       Date:  2019-09-21

2.  In vitro activities of levofloxacin used alone and in combination with first- and second-line antituberculous drugs against Mycobacterium tuberculosis.

Authors:  N Rastogi; K S Goh; A Bryskier; A Devallois
Journal:  Antimicrob Agents Chemother       Date:  1996-07       Impact factor: 5.191

3.  Approach to the diagnosis and treatment of non-tuberculous mycobacterial disease.

Authors:  Kelly M Pennington; Ann Vu; Douglas Challener; Christina G Rivera; F N U Shweta; John D Zeuli; Zelalem Temesgen
Journal:  J Clin Tuberc Other Mycobact Dis       Date:  2021-05-08
  3 in total

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