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Literature DB >> 3919625

In vitro antituberculosis activity of a new antibacterial substance ofloxacin (DL8280).

Abstract

A new antituberculosis agent, ofloxacin (DL8280), inhibited the growth of Mycobacterium tuberculosis at concentrations of 0.63 to 1.25 micrograms/ml. There were no cross-resistance relationships between this agent and other antituberculosis agents. The agent delayed the growth rate of M. tuberculosis (strain H37Rv) at concentrations of 0.2 to 0.5 microgram/ml. It showed considerable bactericidal activity at concentrations a little higher than the growth-inhibitory concentration. The combined effect with other antituberculosis agents seemed to be additive. The pattern of resistance that developed with this agent was the obligatory two-step pattern, and there were 2 resistant phenotypes.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1985 PMID： 3919625 DOI： 10.1164/arrd.1985.131.3.348

Source DB: PubMed Journal: Am Rev Respir Dis ISSN： 0003-0805

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Cited

18 in total

1. Effect of ofloxacin combined with Lactobacillus casei against Mycobacterium fortuitum infection induced in mice.

Authors: H Tomioka; K Sato; H Saito
Journal: Antimicrob Agents Chemother Date: 1990-04 Impact factor: 5.191

2. Moxifloxacin (BAY12-8039), a new 8-methoxyquinolone, is active in a mouse model of tuberculosis.

Authors: E Miyazaki; M Miyazaki; J M Chen; R E Chaisson; W R Bishai
Journal: Antimicrob Agents Chemother Date: 1999-01 Impact factor: 5.191

Review 3. Mycobacteria and the new quinolones.

Authors: D C Leysen; A Haemers; S R Pattyn
Journal: Antimicrob Agents Chemother Date: 1989-01 Impact factor: 5.191

4. MICs and MBCs of Win 57273 against Mycobacterium avium and M. tuberculosis.

Authors: L B Heifets; P J Lindholm-Levy
Journal: Antimicrob Agents Chemother Date: 1990-05 Impact factor: 5.191

5. Bactericidal action of ofloxacin, sulbactam-ampicillin, rifampin, and isoniazid on logarithmic- and stationary-phase cultures of Mycobacterium tuberculosis.

Authors: D Herbert; C N Paramasivan; P Venkatesan; G Kubendiran; R Prabhakar; D A Mitchison
Journal: Antimicrob Agents Chemother Date: 1996-10 Impact factor: 5.191

10. Diffusion of oral ofloxacin (HOE 280) into human prostatic tissue: assessment by an improved high-performance liquid chromatographic method.

Authors: R Claes; Y Dusart; J C Dupont; B Jeanbaptiste; M Podoor; J Douchamps
Journal: Infection Date: 1986 Impact factor: 3.553

In vitro antituberculosis activity of a new antibacterial substance ofloxacin (DL8280).

1. Effect of ofloxacin combined with Lactobacillus casei against Mycobacterium fortuitum infection induced in mice.

2. Moxifloxacin (BAY12-8039), a new 8-methoxyquinolone, is active in a mouse model of tuberculosis.

Review 3. Mycobacteria and the new quinolones.

4. MICs and MBCs of Win 57273 against Mycobacterium avium and M. tuberculosis.

5. Bactericidal action of ofloxacin, sulbactam-ampicillin, rifampin, and isoniazid on logarithmic- and stationary-phase cultures of Mycobacterium tuberculosis.

6. In vitro and in vivo antimycobacterial activities of a new quinolone, DU-6859a.

7. Inhibition of theophylline clearance by coadministered ofloxacin without alteration of theophylline effects.

8. Ofloxacin penetration into tuberculous pleural effusion.

9. In vitro activity of levofloxacin, singly and in combination with rifamycin analogs, against Mycobacterium leprae.

10. Diffusion of oral ofloxacin (HOE 280) into human prostatic tissue: assessment by an improved high-performance liquid chromatographic method.