Literature DB >> 8534201

Production, characterization and application of monoclonal antibodies against the organophosphorus nerve agent Vx.

Y X Ci1, Y X Zhou, Z Q Guo, K T Rong, W B Chang.   

Abstract

Two monoclonal antibodies (Vx-BB8 and Vx-EA11) to the chemical warfare agent Vx were produced and characterized. A competitive inhibition enzyme immunoassay was developed to detect Vx concentrations as low as 3.7 x 10(-7) - 3.7 x 10(-6) mol/l in biological samples. Vx-BB8 400 micrograms given intravenously immediately before 1 x LD95 Vx or 400 micrograms Vx-BB8 intraperitoneally 1.5 h-3 days before 1 x LD95 Vx could protect all the tested mice from death.

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Year:  1995        PMID： 8534201     DOI： 10.1007/s002040050213

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  10 in total

1.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

2.  Detection of the organophosphorus nerve agent soman by an ELISA using monoclonal antibodies.

Authors:  M H Erhard; R Kühlmann; L Szinicz; U Lösch
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

3.  Application of an enzyme-linked immunosorbent assay (ELISA) to determine paraquat residues in milk, beef, and potatoes.

Authors:  J Van Emon; J Seiber; B Hammock
Journal:  Bull Environ Contam Toxicol       Date:  1987-09       Impact factor: 2.151

4.  Quantification of the organophosphorus nerve agent soman by competitive inhibition enzyme immunoassay using monoclonal antibody.

Authors:  K W Hunter; D E Lenz; A A Brimfield; J A Naylor
Journal:  FEBS Lett       Date:  1982-11-22       Impact factor: 4.124

5.  Detection and quantification of the organophosphate insecticide paraoxon by competitive inhibition enzyme immunoassay.

Authors:  K W Hunter; D E Lenz
Journal:  Life Sci       Date:  1982-01-25       Impact factor: 5.037

6.  Immunologic protection against VX intoxication in experimental animals.

Authors:  K T Rong; L J Zhang
Journal:  Pharmacol Toxicol       Date:  1990-09

7.  Studies using a monoclonal antibody against soman.

Authors:  D E Lenz; A A Brimfield; K W Hunter; H P Benschop; L P de Jong; C van Dijk; T R Clow
Journal:  Fundam Appl Toxicol       Date:  1984-04

8.  A competitive inhibition enzyme immunoassay for detection and quantification of organophosphorus compounds.

Authors:  P Schmidt; R Kühlmann; U Lösch
Journal:  Z Naturforsch C J Biosci       Date:  1988 Mar-Apr

9.  A modified ELISA technique for anti-hapten antibodies.

Authors:  M Suter
Journal:  J Immunol Methods       Date:  1982-08-27       Impact factor: 2.303

10.  Development of an ELISA for detection of an organophosphorus compound using monoclonal antibodies.

Authors:  M H Erhard; P Schmidt; R Kühlmann; U Lösch
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153
  10 in total

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