Literature DB >> 852872

Benzpyrene-induced sister chromatid exchanges in lymphocytes of patients with lung cancer.

A D Schönwald, C R Bartram, H W Rüdiger.   

Abstract

The effect of benzpyrene on sister chromatid exchange was determined in PHA-stimulated lymphocytes of 18 patients with lung cancer and 11 controls without cancer or bronchopulmonary diseases. Patients and controls did not differ either with respect to the spontaneous rate of sister chromatid exchanges or in their response to the carcinogen. We conclude that individual susceptibility to lung cancer cannot be detected by an individual response to benzypyrene, at least in lymphocytes and at the chromosomal level.

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Year:  1977        PMID： 852872     DOI： 10.1007/BF00446274

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  14 in total

1.  The role of cell division in the malignant transformation of mouse cells treated with 3-methylcholanthrene.

Authors:  T Kakunaga
Journal:  Cancer Res       Date:  1975-07       Impact factor: 12.701

2.  Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes.

Authors:  S A Latt
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

3.  Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.

Authors:  G Kellermann; C R Shaw; M Luyten-Kellerman
Journal:  N Engl J Med       Date:  1973-11-01       Impact factor: 91.245

Review 4.  Experimental tobacco carcinogenesis.

Authors:  E L Wynder; D Hoffmann
Journal:  Science       Date:  1968-11-22       Impact factor: 47.728

5.  Reactivity of the K-region epoxides of some polycyclic hydrocarbons towards the nucleic acids and proteins of BHK 21 cells.

Authors:  P L Grover; J A Forrester; P Sims
Journal:  Biochem Pharmacol       Date:  1971-06       Impact factor: 5.858

6.  The binding of polycyclic aromatic hydrocarbons to the DNA, RNA, and proteins of transformable cells in culture.

Authors:  T Kuroki; C Heidelberger
Journal:  Cancer Res       Date:  1971-12       Impact factor: 12.701

7.  Separation of leukocytes from blood and bone marrow. Introduction.

Authors:  A Böyum
Journal:  Scand J Clin Lab Invest Suppl       Date:  1968

8.  Epoxides metabolically produced from some known carcinogens and from some clinically used drugs. I. Differences in mutagenicity.

Authors:  H R Glatt; F Oesch; A Frigerio; S Garattini
Journal:  Int J Cancer       Date:  1975-11-15       Impact factor: 7.396

9.  Letter: Cigarette smoking, tar content, and death-rates from lung cancer in Australian men.

Authors:  N Gray; D Hill
Journal:  Lancet       Date:  1975-05-31       Impact factor: 79.321

10.  Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.

Authors:  P Perry; H J Evans
Journal:  Nature       Date:  1975-11-13       Impact factor: 49.962
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  3 in total

1.  Sister chromatid exchanges in the peripheral blood of cigarette smokers and in lung cancer patients; and the effect of chemotherapy.

Authors:  D H Hollander; M S Tockman; Y W Liang; D S Borgaonkar; J K Frost
Journal:  Hum Genet       Date:  1978-10-31       Impact factor: 4.132

2.  Decreased rate of benzo(a)pyrene-induced sister chromatid exchange in fibroblast cultures from patients with lung cancer.

Authors:  H W Rüdiger; W Harder; P Maack; F V Kohl; U Schmidt-Preuss
Journal:  J Cancer Res Clin Oncol       Date:  1981       Impact factor: 4.553

3.  Cultured mouse embryos metabolize benzo[a]pyrene during early gestation: genetic differences detectable by sister chromatid exchange.

Authors:  S M Galloway; P E Perry; J Meneses; D W Nebert; R A Pedersen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205
  3 in total

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