Literature DB >> 8524655

The effects of the ring fragmentation product of thymidine C5-hydrate on phosphodiesterases and klenow (exo-) fragment.

T J Matray1, K J Haxton, M M Greenberg.   

Abstract

N-(2-Deoxy-beta-D-erythro-pentofuranosyl)-N-3-(2R-hydroxyisobutyric acid)urea (alpha-R-hydroxy-beta-ureidoisobutyric acid, 8) was site specifically incorporated into a series of oligonucleotides via the ammonolysis of biopolymers containing 5R-thymidine C5-hydrate (3). alpha-R-hydroxy-beta-ureidoisobutyric acid (8) inhibits snake venom phosphodiesterase, lambda exonuclease and Klenow (exo-) fragment. Kinetic measurements for insertion of nucleotides opposite 8 by Klenow (exo-) fragment indicate that this lesion is instructive.

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Year:  1995        PMID： 8524655      PMCID： PMC307438          DOI： 10.1093/nar/23.22.4642

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  16 in total

1.  Modification of bases in DNA by copper ion-1,10-phenanthroline complexes.

Authors:  M Dizdaroglu; O I Aruoma; B Halliwell
Journal:  Biochemistry       Date:  1990-09-11       Impact factor: 3.162

Review 2.  Biochemical basis of DNA replication fidelity.

Authors:  M F Goodman; S Creighton; L B Bloom; J Petruska
Journal:  Crit Rev Biochem Mol Biol       Date:  1993       Impact factor: 8.250

3.  Thymine ring saturation and fragmentation products: lesion bypass, misinsertion and implications for mutagenesis.

Authors:  J Evans; M Maccabee; Z Hatahet; J Courcelle; R Bockrath; H Ide; S Wallace
Journal:  Mutat Res       Date:  1993-05       Impact factor: 2.433

4.  Translesional synthesis on DNA templates containing 8-oxo-7,8-dihydrodeoxyadenosine.

Authors:  S Shibutani; V Bodepudi; F Johnson; A P Grollman
Journal:  Biochemistry       Date:  1993-05-04       Impact factor: 3.162

5.  Influence of abasic and anucleosidic sites on the stability, conformation, and melting behavior of a DNA duplex: correlations of thermodynamic and structural data.

Authors:  G Vesnaver; C N Chang; M Eisenberg; A P Grollman; K J Breslauer
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

6.  Inhibition of DNA polymerase activity by thymine hydrates.

Authors:  T Ganguly; N J Duker
Journal:  Mutat Res       Date:  1992-11       Impact factor: 2.433

7.  A novel method for site specific introduction of single model oxidative DNA lesions into oligodeoxyribonucleotides.

Authors:  Z Hatahet; A A Purmal; S S Wallace
Journal:  Nucleic Acids Res       Date:  1993-04-11       Impact factor: 16.971

8.  Influence of nucleic acid base aromaticity on substrate reactivity with enzymes acting on single-stranded DNA.

Authors:  M Weinfeld; K J Soderlind; G W Buchko
Journal:  Nucleic Acids Res       Date:  1993-02-11       Impact factor: 16.971

9.  Solution conformation of an oligonucleotide containing a urea deoxyribose residue in front of a thymine.

Authors:  V Gervais; A Guy; R Téoule; G V Fazakerley
Journal:  Nucleic Acids Res       Date:  1992-12-25       Impact factor: 16.971

10.  Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.

Authors:  S Shibutani; M Takeshita; A P Grollman
Journal:  Nature       Date:  1991-01-31       Impact factor: 49.962
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  2 in total

1.  Substrate and mispairing properties of 5-formyl-2'-deoxyuridine 5'-triphosphate assessed by in vitro DNA polymerase reactions.

Authors:  M Yoshida; K Makino; H Morita; H Terato; Y Ohyama; H Ide
Journal:  Nucleic Acids Res       Date:  1997-04-15       Impact factor: 16.971

2.  Unexpected role for Helicobacter pylori DNA polymerase I as a source of genetic variability.

Authors:  María-Victoria García-Ortíz; Stéphanie Marsin; Mercedes E Arana; Didier Gasparutto; Raphaël Guérois; Thomas A Kunkel; J Pablo Radicella
Journal:  PLoS Genet       Date:  2011-06-23       Impact factor: 5.917
  2 in total

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