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Literature DB >> 8523590

bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation.

C W Olsen¹, J C Kehren, N R Dybdahl-Sissoko, V S Hinshaw.

Abstract

We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infected at a low multiplicity of infection. This effect is associated with modified glycosylation of the hemagglutinin protein.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1996 PMID： 8523590 PMCID： PMC189863

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

13 in total

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Authors: H Van Campen; B C Easterday; V S Hinshaw
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Review 10. Bcl-2 and the regulation of programmed cell death.

Authors: J C Reed
Journal: J Cell Biol Date: 1994-01 Impact factor: 10.539

39 in total

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Journal: Microbiol Mol Biol Rev Date: 2000-12 Impact factor: 11.056

2. Effect of enforced expression of human bcl-2 on Japanese encephalitis virus-induced apoptosis in cultured cells.

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Journal: J Virol Date: 1997-08 Impact factor: 5.103

3. Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.

Authors: Christina Ehrhardt; Thorsten Wolff; Stephan Pleschka; Oliver Planz; Wiebke Beermann; Johannes G Bode; Mirco Schmolke; Stephan Ludwig
Journal: J Virol Date: 2007-01-17 Impact factor: 5.103

4. Lack of Bax prevents influenza A virus-induced apoptosis and causes diminished viral replication.

Authors: Jeffrey E McLean; Emmanuel Datan; Demetrius Matassov; Zahra F Zakeri
Journal: J Virol Date: 2009-06-03 Impact factor: 5.103

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Journal: J Virol Date: 1997-03 Impact factor: 5.103

Review 6. From threat to cure: understanding of virus-induced cell death leads to highly immunogenic oncolytic influenza viruses.

Authors: Julijan Kabiljo; Johannes Laengle; Michael Bergmann
Journal: Cell Death Discov Date: 2020-06-11

7. Cellular protein HAX1 interacts with the influenza A virus PA polymerase subunit and impedes its nuclear translocation.

Authors: Wei-Bin Hsu; Jia-Ling Shih; Jie-Ru Shih; Jia-Ling Du; Shu-Chun Teng; Li-Min Huang; Won-Bo Wang
Journal: J Virol Date: 2012-10-10 Impact factor: 5.103

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Authors: Walter J Wurzer; Oliver Planz; Christina Ehrhardt; Martin Giner; Tobias Silberzahn; Stephan Pleschka; Stephan Ludwig
Journal: EMBO J Date: 2003-06-02 Impact factor: 11.598

10. Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes.

Authors: Cristian Cillóniz; Kyoko Shinya; Xinxia Peng; Marcus J Korth; Sean C Proll; Lauri D Aicher; Victoria S Carter; Jean H Chang; Darwyn Kobasa; Friedericke Feldmann; James E Strong; Heinz Feldmann; Yoshihiro Kawaoka; Michael G Katze
Journal: PLoS Pathog Date: 2009-10-02 Impact factor: 6.823