Literature DB >> 8515214

Aspartic acid racemization in intervertebral discs as an aid to postmortem estimation of age at death.

S Ritz1, H W Schütz.   

Abstract

We investigated whether measurement of aspartic acid racemization in intervertebral discs (IVD) could be used in the postmortem estimation of age at death. The extent of aspartic acid racemization in IVD tissues was found to increase with age. The rate of racemization turned out to be much higher in the nucleus pulposus than in the annulus fibrosus. The relation between age and the D-aspartic acid content in the anterior peripheral annulus fibrosus of IVD was close enough to allow postmortem estimation of age at death based on the extent of aspartic acid racemization in this tissue.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8515214

Source DB:  PubMed          Journal:  J Forensic Sci        ISSN： 0022-1198            Impact factor:   1.832


  14 in total

1.  Age estimation based on aspartic acid racemization in elastin from the yellow ligaments.

Authors:  S Ritz-Timme; I Laumeier; M Collins
Journal:  Int J Legal Med       Date:  2003-02-28       Impact factor: 2.686

2.  Age estimation based on aspartic acid racemization in human sclera.

Authors:  Karolin Klumb; Christian Matzenauer; Alexandra Reckert; Klaus Lehmann; Stefanie Ritz-Timme
Journal:  Int J Legal Med       Date:  2015-08-25       Impact factor: 2.686

3.  Racemization of two proteins over our lifespan: deamidation of asparagine 76 in γS crystallin is greater in cataract than in normal lenses across the age range.

Authors:  Michelle Yu Sung Hooi; Mark J Raftery; Roger John Willis Truscott
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-06-14       Impact factor: 4.799

Review 4.  Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc.

Authors:  Sarit Sara Sivan; Anthony J Hayes; Ellen Wachtel; Bruce Caterson; Yulia Merkher; Alice Maroudas; Sharon Brown; Sally Roberts
Journal:  Eur Spine J       Date:  2013-04-17       Impact factor: 3.134

5.  Age estimation based on different molecular clocks in several tissues and a multivariate approach: an explorative study.

Authors:  Julia Becker; Nina Sophia Mahlke; A Reckert; S B Eickhoff; S Ritz-Timme
Journal:  Int J Legal Med       Date:  2019-04-11       Impact factor: 2.686

6.  Racemisation and human cataract. D-Ser, D-Asp/Asn and D-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses.

Authors:  Michelle Yu Sung Hooi; Roger J W Truscott
Journal:  Age (Dordr)       Date:  2010-08-05

Review 7.  Predicting protein decomposition: the case of aspartic-acid racemization kinetics.

Authors:  M J Collins; E R Waite; A C van Duin
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-01-29       Impact factor: 6.237

8.  Age estimation based on aspartic acid racemization in dentine: what about caries-affected teeth?

Authors:  Nazan Sirin; Christian Matzenauer; Alexandra Reckert; Stefanie Ritz-Timme
Journal:  Int J Legal Med       Date:  2017-08-19       Impact factor: 2.686

9.  Estimation of age at death based on aspartic acid racemization in elastic cartilage of the epiglottis.

Authors:  Christian Matzenauer; Alexandra Reckert; Stefanie Ritz-Timme
Journal:  Int J Legal Med       Date:  2013-11-12       Impact factor: 2.686

10.  Aspartic acid racemisation in purified elastin from arteries as basis for age estimation.

Authors:  R C Dobberstein; S-M Tung; S Ritz-Timme
Journal:  Int J Legal Med       Date:  2009-11-19       Impact factor: 2.686
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.