Literature DB >> 8514452

Expression of MMP-7(PUMP-1) mRNA in human colorectal cancers.

M Yoshimoto1, F Itoh, H Yamamoto, Y Hinoda, K Imai, A Yachi.   

Abstract

The expression of MMP-7 (pump-1) gene was examined in 10 cases of colorectal cancer by utilizing RT-PCR. In 9 out of 10 cases, MMP-7 mRNA was detected in cancerous tissue, whereas none was detected in adjacent normal colon tissue. However, this message was detected in only 1 out of 6 colon-cancer cell lines. In colonic mucosa from 3 patients with ulcerative colitis it was not detected. The expression of MMP-2 (72-kDa type-IV collagenase) mRNA was also investigated in the same tissue samples, and was detected in all samples, including cancerous and non-cancerous tissue. Our data suggest that MMP-7 is expressed in a tumor-associated manner in colorectal cancers and may play a role in tumor progression.

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Year:  1993        PMID： 8514452     DOI： 10.1002/ijc.2910540415

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  33 in total

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Review 4.  Matrix metalloproteinase inhibitors: present achievements and future prospects.

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5.  Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro.

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6.  Proteolysis in colorectal cancer.

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Review 7.  An overview of clinical trials involving inhibitors of angiogenesis and their mechanism of action.

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9.  Relation of matrilysin messenger RNA expression with invasive activity in human gastric cancer.

Authors:  A Senota; F Itoh; H Yamamoto; Y Adachi; Y Hinoda; K Imai
Journal:  Clin Exp Metastasis       Date:  1998-05       Impact factor: 5.150

10.  SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity.

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