Literature DB >> 8514133

Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus.

D R Dorer1, M A Cadden, B Gordesky-Gold, G Harries, A C Christensen.   

Abstract

One of the most extreme examples of gene dosage sensitivity is the Triplo-lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the suppression is a gene dosage effect. Altered dosage of Isis in the presence of two copies of Tpl has no obvious effects. By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl.

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Mesh：

Year:  1993        PMID： 8514133      PMCID： PMC1205427     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  21 in total

1.  Evidence for a Sex-Linked Haplo-Inviable Locus in the Cut-Singed Region of DROSOPHILA MELANOGASTER.

Authors:  G Lefevre; T K Johnson
Journal:  Genetics       Date:  1973-08       Impact factor: 4.562

2.  Analysis of P transposable element functions in Drosophila.

Authors:  R E Karess; G M Rubin
Journal:  Cell       Date:  1984-08       Impact factor: 41.582

3.  Mutational Events in the Triplo- and Haplo-Lethal Region (83de) of the DROSOPHILA MELANOGASTER Genome.

Authors:  R L Roehrdanz; J C Lucchesi
Journal:  Genetics       Date:  1980-06       Impact factor: 4.562

Review 4.  Gene dosage compensation in Drosophila melanogaster.

Authors:  J C Lucchesi; J E Manning
Journal:  Adv Genet       Date:  1987       Impact factor: 1.944

5.  The genetic analysis of a uniquely dose-sensitive chromosomal region of Drosophila melanogaster.

Authors:  R E Denell
Journal:  Genetics       Date:  1976-10       Impact factor: 4.562

Review 6.  Sex determination and dosage compensation in Drosophila melanogaster.

Authors:  B S Baker; J M Belote
Journal:  Annu Rev Genet       Date:  1983       Impact factor: 16.830

7.  The unusual spectrum of mutations induced by hybrid dysgenesis at the Triplo-lethal locus of Drosophila melanogaster.

Authors:  D R Dorer; A C Christensen
Journal:  Genetics       Date:  1990-08       Impact factor: 4.562

8.  Evidence that sisterless-a and sisterless-b are two of several discrete "numerator elements" of the X/A sex determination signal in Drosophila that switch Sxl between two alternative stable expression states.

Authors:  T W Cline
Journal:  Genetics       Date:  1988-08       Impact factor: 4.562

9.  The effect of chromosomal position on the expression of the Drosophila xanthine dehydrogenase gene.

Authors:  A C Spradling; G M Rubin
Journal:  Cell       Date:  1983-08       Impact factor: 41.582

10.  Constructing deletions with defined endpoints in Drosophila.

Authors:  L Cooley; D Thompson; A C Spradling
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205
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  3 in total

1.  A genetic screen of the Drosophila X chromosome for mutations that modify Deformed function.

Authors:  B Florence; W McGinnis
Journal:  Genetics       Date:  1998-12       Impact factor: 4.562

2.  A family of genes clustered at the Triplo-lethal locus of Drosophila melanogaster has an unusual evolutionary history and significant synteny with Anopheles gambiae.

Authors:  Douglas R Dorer; Jamie A Rudnick; Etsuko N Moriyama; Alan C Christensen
Journal:  Genetics       Date:  2003-10       Impact factor: 4.562

3.  The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function.

Authors:  A Prado; I Canal; A Ferrús
Journal:  Genetics       Date:  1999-01       Impact factor: 4.562
  3 in total

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