| Literature DB >> 8508924 |
T E Webb1, J Simon, B J Krishek, A N Bateson, T G Smart, B F King, G Burnstock, E A Barnard.
Abstract
A cDNA encoding a novel member of the G-protein-coupled receptor (GCR) superfamily, an ATP receptor, has been isolated from an embryonic chick whole brain cDNA library by hybridization screening. The encoded protein has a sequence of 362 amino acids (41 kDa) and shares no more than 27% amino acid identity with any known GCR. When expressed as a complementary RNA (cRNA) in Xenopus oocytes a slowly-developing inward current was observed in response to application of ATP. The pharmacology of this expressed protein defines it as a P2Y purinoceptor.Entities:
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Year: 1993 PMID： 8508924 DOI： 10.1016/0014-5793(93)81397-i
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124