Literature DB >> 8506383

DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues.

V Brabec1, M Leng.   

Abstract

Bases in the opposite strands of DNA cross-linked by clinically ineffective trans-diamminedichloroplatinum(II) (trans-[Pt(NH3)2Cl2]) have been identified by means of three experimental approaches. These include HPLC analysis of enzymatic digests of synthetic oligonucleotide duplexes containing the interstrand cross-link, footprinting experiments on the interstrand cross-linked oligonucleotide duplexes, and termination of the duplex transcription on trans-[Pt(NH3)2Cl2]-treated fragments of plasmid DNA. The results reveal that deoxyguanine and complementary deoxycytosine residues are preferential binding sites of trans-[Pt(NH3)2Cl2] in the interstrand adducts. The interstrand cross-linking reaction was studied by means of gel electrophoresis for the cis and trans isomers. The rate of formation of interstrand cross-links was lower for the trans isomer; however, trans-[Pt(NH3)2Cl2] formed about twice the amount of interstrand cross-links as compared with the cis isomer after 48 hr. The present results are suggested to be relevant to differences in clinical activity of the two platinum(II) isomers.

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Year:  1993        PMID： 8506383      PMCID： PMC46713          DOI： 10.1073/pnas.90.11.5345

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Transcription by eucaryotic and procaryotic RNA polymerases of DNA modified at a d(GG) or a d(AG) site by the antitumor drug cis-diamminedichloroplatinum(II).

Authors:  Y Corda; C Job; M F Anin; M Leng; D Job
Journal:  Biochemistry       Date:  1991-01-08       Impact factor: 3.162

2.  Transcription from bacteriophage T7 and SP6 RNA polymerase promoters in the presence of 3'-deoxyribonucleoside 5'-triphosphate chain terminators.

Authors:  V D Axelrod; F R Kramer
Journal:  Biochemistry       Date:  1985-10-08       Impact factor: 3.162

3.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

Review 4.  The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes.

Authors:  A Eastman
Journal:  Pharmacol Ther       Date:  1987       Impact factor: 12.310

5.  Synthesis and characterization of trans-[Pt(NH3)2Cl2] adducts of d(CCTCGAGTCTCC).d(GGAGACTCGAGG).

Authors:  C A Lepre; L Chassot; C E Costello; S J Lippard
Journal:  Biochemistry       Date:  1990-01-23       Impact factor: 3.162

6.  Characterization of bifunctional adducts produced in DNA by trans-diamminedichloroplatinum(II).

Authors:  A Eastman; M M Jennerwein; D L Nagel
Journal:  Chem Biol Interact       Date:  1988       Impact factor: 5.192

7.  Kinetic analysis of the in vitro binding of radioactive cis- and trans-dichlorodiammineplatinum(II) to DNA.

Authors:  N P Johnson; J D Hoeschele; R O Rahn
Journal:  Chem Biol Interact       Date:  1980-05       Impact factor: 5.192

8.  Interaction of trans-diamminedichloroplatinum(II) with DNA: formation of monofunctional adducts and their reaction with glutathione.

Authors:  A Eastman; M A Barry
Journal:  Biochemistry       Date:  1987-06-16       Impact factor: 3.162

9.  Sequence-dependent distortions induced in DNA by monofunctional platinum(II) binding.

Authors:  V Brabec; J Reedijk; M Leng
Journal:  Biochemistry       Date:  1992-12-15       Impact factor: 3.162

10.  Identification and characterization of a novel linkage isomerization in the reaction of trans-diamminedichloroplatinum(II) with 5'-d(TCTACGCGTTCT).

Authors:  K M Comess; C E Costello; S J Lippard
Journal:  Biochemistry       Date:  1990-02-27       Impact factor: 3.162
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  57 in total

1.  Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex.

Authors:  C Hofr; N Farrell; V Brabec
Journal:  Nucleic Acids Res       Date:  2001-05-15       Impact factor: 16.971

2.  Antitumor bifunctional dinuclear Pt(II) complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions.

Authors:  Tereza Muchova; Susana M Quintal; Nicholas P Farrell; Viktor Brabec; Jana Kasparkova
Journal:  J Biol Inorg Chem       Date:  2011-09-21       Impact factor: 3.358

3.  Formation of platinated GG cross-links on DNA by photoactivation of a platinum(IV) azide complex.

Authors:  Jana Kaspárková; Fiona S Mackay; Viktor Brabec; Peter J Sadler
Journal:  J Biol Inorg Chem       Date:  2003-07-09       Impact factor: 3.358

4.  Pt-bridges in various single-strand and double-helix DNA sequences. DFT and MP2 study of the cisplatin coordination with guanine, adenine, and cytosine.

Authors:  Matej Pavelka; Jaroslav V Burda
Journal:  J Mol Model       Date:  2006-09-20       Impact factor: 1.810

Review 5.  Formation and repair of interstrand cross-links in DNA.

Authors:  David M Noll; Tracey McGregor Mason; Paul S Miller
Journal:  Chem Rev       Date:  2006-02       Impact factor: 60.622

6.  Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2].

Authors:  Erin Wachter; Ana Zamora; David K Heidary; José Ruiz; Edith C Glazer
Journal:  Chem Commun (Camb)       Date:  2016-08-09       Impact factor: 6.222

7.  Substrate specificity and sequence-dependent activity of the Saccharomyces cerevisiae 3-methyladenine DNA glycosylase (Mag).

Authors:  Gondichatnahalli M Lingaraju; Maria Kartalou; Lisiane B Meira; Leona D Samson
Journal:  DNA Repair (Amst)       Date:  2008-05-12

8.  Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand.

Authors:  Yousef Najajreh; Jana Kasparkova; Victoria Marini; Dan Gibson; Viktor Brabec
Journal:  J Biol Inorg Chem       Date:  2005-11-08       Impact factor: 3.358

9.  Effects of monofunctional adducts of platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes.

Authors:  Vendula Bursova; Jana Kasparkova; Ctirad Hofr; Viktor Brabec
Journal:  Biophys J       Date:  2004-12-01       Impact factor: 4.033

10.  Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers.

Authors:  Haimei Chen; John A Parkinson; Olga Nováková; Juraj Bella; Fuyi Wang; Alice Dawson; Robert Gould; Simon Parsons; Viktor Brabec; Peter J Sadler
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205
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