Literature DB >> 27352966

Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2].

Erin Wachter1, Ana Zamora2, David K Heidary1, José Ruiz2, Edith C Glazer1.   

Abstract

Two thermally activated ruthenium(ii) polypyridyl complexes, cis-Ru(bpy)2Cl2 and trans-Ru(qpy)Cl2 were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requirements for cisplatin, trans-Ru(qpy)Cl2 was 7.1-9.5× more cytotoxic than cis-Ru(bpy)2Cl2. This discovery could open up a new area of metal-based chemotherapeutic research.

Entities:  

Year:  2016        PMID： 27352966      PMCID： PMC4980196          DOI： 10.1039/c6cc04813g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  30 in total

Review 1.  Current status of the development of trans-platinum antitumor drugs.

Authors:  J M Pérez; M A Fuertes; C Alonso; C Navarro-Ranninger
Journal:  Crit Rev Oncol Hematol       Date:  2000-08       Impact factor: 6.312

2.  Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile.

Authors:  Ga Young Park; Justin J Wilson; Ying Song; Stephen J Lippard
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-06       Impact factor: 11.205

3.  Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma.

Authors:  Christine Billecke; Susan Finniss; Laura Tahash; Cathie Miller; Tom Mikkelsen; Nicholas P Farrell; Oliver Bögler
Journal:  Neuro Oncol       Date:  2006-05-24       Impact factor: 12.300

4.  Effect of cis-, trans-diamminedichloroplatinum(II) and DBP on human serum albumin.

Authors:  L Trynda-Lemiesz; H Kozłowski; B K Keppler
Journal:  J Inorg Biochem       Date:  1999 Nov-Dec       Impact factor: 4.155

5.  DNA conformational change produced by the site-specific interstrand cross-link of trans-diamminedichloroplatinum(II).

Authors:  V Brabec; M Síp; M Leng
Journal:  Biochemistry       Date:  1993-11-02       Impact factor: 3.162

6.  Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic.

Authors:  Oldrich Vrana; Vojtech Novohradsky; Zdenka Medrikova; Jana Burdikova; Olga Stuchlikova; Jana Kasparkova; Viktor Brabec
Journal:  Chemistry       Date:  2016-01-20       Impact factor: 5.236

7.  Towards Antitumor Active trans-Platinum Compounds.

Authors:  Sheena M Aris; Nicholas P Farrell
Journal:  Eur J Inorg Chem       Date:  2009-04-01       Impact factor: 2.524

8.  DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)].

Authors:  A Zákovská; O Nováková; Z Balcarová; U Bierbach; N Farrell; V Brabec
Journal:  Eur J Biochem       Date:  1998-06-15

9.  Solution structure of a cisplatin-induced DNA interstrand cross-link.

Authors:  H Huang; L Zhu; B R Reid; G P Drobny; P B Hopkins
Journal:  Science       Date:  1995-12-15       Impact factor: 47.728

Review 10.  The resurgence of platinum-based cancer chemotherapy.

Authors:  Lloyd Kelland
Journal:  Nat Rev Cancer       Date:  2007-07-12       Impact factor: 60.716
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  5 in total

1.  Amino-Functionalized Mesoporous Silica Nanoparticle-Encapsulated Octahedral Organoruthenium Complex as an Efficient Platform for Combatting Cancer.

Authors:  Marina Martínez-Carmona; Quy P Ho; Jérémy Morand; Ana García; Enrique Ortega; Luiza C S Erthal; Eduardo Ruiz-Hernandez; M Dolores Santana; José Ruiz; Maria Vallet-Regí; Yurii K Gun'ko
Journal:  Inorg Chem       Date:  2020-07-06       Impact factor: 5.165

Review 2.  The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials.

Authors:  Leli Zeng; Pranav Gupta; Yanglu Chen; Enju Wang; Liangnian Ji; Hui Chao; Zhe-Sheng Chen
Journal:  Chem Soc Rev       Date:  2017-10-02       Impact factor: 54.564

3.  Ruthenium (II) and Iridium (III) Complexes of N-Heterocyclic Carbene and Pyridinol Derived Bidentate Chelates: Synthesis, Characterization, and Reactivity.

Authors:  Deidra L Gerlach; Sopheavy Siek; Dalton B Burks; Jamie M Tesh; Courtney R Thompson; Robert M Vasquez; Nicholas J White; Matthias Zeller; Douglas B Grotjahn; Elizabeth T Papish
Journal:  Inorganica Chim Acta       Date:  2017-07-01       Impact factor: 2.545

4.  Ru(ii) complexes with diazine ligands: electronic modulation of the coordinating group is key to the design of "dual action" photoactivated agents.

Authors:  Dmytro Havrylyuk; Megha Deshpande; Sean Parkin; Edith C Glazer
Journal:  Chem Commun (Camb)       Date:  2018-11-01       Impact factor: 6.222

5.  Fine-Feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity†.

Authors:  Houston D Cole; John A Roque; Liubov M Lifshits; Rachel Hodges; Patrick C Barrett; Dmytro Havrylyuk; David Heidary; Elamparuthi Ramasamy; Colin G Cameron; Edith C Glazer; Sherri A McFarland
Journal:  Photochem Photobiol       Date:  2021-03-28       Impact factor: 3.521
  5 in total

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