Literature DB >> 8505288

Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin.

G Schiavo1, C C Shone, O Rossetto, F C Alexander, C Montecucco.   

Abstract

Botulinum neurotoxin serotype F contains the zinc binding motif of zinc endopeptidases. Atomic adsorption analysis of highly purified toxin preparation revealed the presence of one atom of zinc per molecule of toxin, which could be removed with EDTA or o-phenanthroline. The light chain of the neurotoxin was shown to have a zinc-dependent protease activity specific for VAMP/synaptobrevin, an integral membrane protein of synaptic vesicles. Both isoforms of rat VAMP were cleaved at the same site corresponding to the single Gln-Lys peptide bond present in their sequences. This proteolytic activity was inhibited by EDTA, o-phenanthroline, and captopril as well as by VAMP peptides spanning the cleavage site.

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Year:  1993        PMID： 8505288

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  81 in total

Review 1.  The use of botulinum toxin for the treatment of gastrointestinal motility disorders.

Authors:  Frank Friedenberg; Satya Gollamudi; Henry P Parkman
Journal:  Dig Dis Sci       Date:  2004-02       Impact factor: 3.199

2.  Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism.

Authors:  Callista B Harper; Sally Martin; Tam H Nguyen; Shari J Daniels; Nickolas A Lavidis; Michel R Popoff; Gordana Hadzic; Anna Mariana; Ngoc Chau; Adam McCluskey; Phillip J Robinson; Frederic A Meunier
Journal:  J Biol Chem       Date:  2011-08-05       Impact factor: 5.157

3.  Mass Spectrometric Identification and Differentiation of Botulinum Neurotoxins through Toxin Proteomics.

Authors:  Suzanne R Kalb; John R Barr
Journal:  Rev Anal Chem       Date:  2013-08       Impact factor: 3.067

Review 4.  Botulinum neurotoxin structure, engineering, and novel cellular trafficking and targeting.

Authors:  B R Singh
Journal:  Neurotox Res       Date:  2006-04       Impact factor: 3.911

5.  A neuronal cell-based botulinum neurotoxin assay for highly sensitive and specific detection of neutralizing serum antibodies.

Authors:  Sabine Pellett; William H Tepp; Colin M Clancy; Gary E Borodic; Eric A Johnson
Journal:  FEBS Lett       Date:  2007-09-12       Impact factor: 4.124

6.  Factors associated with symptom response to pyloric injection of botulinum toxin in a large series of gastroparesis patients.

Authors:  Radoslav Coleski; Michelle A Anderson; William L Hasler
Journal:  Dig Dis Sci       Date:  2009-12       Impact factor: 3.199

7.  Purification and Characterization of Recombinant Botulinum Neurotoxin Serotype FA, Also Known as Serotype H.

Authors:  Gavin Hackett; Kevin Moore; David Burgin; Fraser Hornby; Bryony Gray; Mark Elliott; Imran Mir; Matthew Beard
Journal:  Toxins (Basel)       Date:  2018-05-11       Impact factor: 4.546

8.  Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.

Authors:  Min Dong; Huisheng Liu; William H Tepp; Eric A Johnson; Roger Janz; Edwin R Chapman
Journal:  Mol Biol Cell       Date:  2008-09-24       Impact factor: 4.138

9.  Protein kinase C and clostridial neurotoxins affect discrete and related steps in the secretory pathway.

Authors:  M A Bittner; R W Holz
Journal:  Cell Mol Neurobiol       Date:  1993-12       Impact factor: 5.046

10.  Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F.

Authors:  S Yamasaki; Y Hu; T Binz; A Kalkuhl; H Kurazono; T Tamura; R Jahn; E Kandel; H Niemann
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205
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