Literature DB >> 8500610

The cis/trans interconversion of the calcium regulating hormone calcitonin is catalyzed by cyclophilin.

D Kern1, T Drakenberg, M Wikström, S Forsén, H Bang, G Fischer.   

Abstract

The cytosolic peptidyl-prolyl cis/trans isomerase cyclophilin from pig kidney can accelerate catalytically the cis/trans isomerization of prolyl peptide bonds. One- and two-dimensional 1H NMR spectroscopy was used to prove that the polypeptide hormone calcitonin is a substrate for cyclophilin. Isomerization of only one of the two prolyl peptide bonds is catalyzed significantly. The efficiency of catalysis was calculated by lineshape analysis and NOESY spectroscopy. Cyclosporin A completely blocks the effect of the enzyme on the conformational dynamics of the polypeptide.

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Year:  1993        PMID： 8500610     DOI： 10.1016/0014-5793(93)81338-z

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Folding of barstar C40A/C82A/P27A and catalysis of the peptidyl-prolyl cis/trans isomerization by human cytosolic cyclophilin (Cyp18).

Authors:  R Golbik; G Fischer; A R Fersht
Journal:  Protein Sci       Date:  1999-07       Impact factor: 6.725

2.  Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells.

Authors:  Lionel Berthoux; Sarah Sebastian; Elena Sokolskaja; Jeremy Luban
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-03       Impact factor: 11.205

3.  Conformational transitions and fibrillation mechanism of human calcitonin as studied by high-resolution solid-state 13C NMR.

Authors:  M Kamihira; A Naito; S Tuzi; A Y Nosaka; H Saitô
Journal:  Protein Sci       Date:  2000-05       Impact factor: 6.725

4.  Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells.

Authors:  Elena Sokolskaja; Lionel Berthoux; Jeremy Luban
Journal:  J Virol       Date:  2006-03       Impact factor: 5.103

5.  Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A.

Authors:  Daryl A Bosco; Elan Z Eisenmesser; Susan Pochapsky; Wesley I Sundquist; Dorothee Kern
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-02       Impact factor: 11.205

6.  The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding.

Authors:  Sara M Solbak; Tove R Reksten; Victor Wray; Karsten Bruns; Ole Horvli; Arnt J Raae; Petra Henklein; Peter Henklein; Rene Röder; David Mitzner; Ulrich Schubert; Torgils Fossen
Journal:  BMC Struct Biol       Date:  2010-10-04

7.  Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening.

Authors:  Sangwoo Shim; Joseph P Yuan; Ju Young Kim; Weizhong Zeng; Guo Huang; Aleksandr Milshteyn; Dorothee Kern; Shmuel Muallem; Guo-li Ming; Paul F Worley
Journal:  Neuron       Date:  2009-11-25       Impact factor: 17.173

8.  Redistribution of cyclophilin A to viral factories during vaccinia virus infection and its incorporation into mature particles.

Authors:  Ana Paula V Castro; Técia M U Carvalho; Nissin Moussatché; Clarissa R A Damaso
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

Review 9.  The Ess1 prolyl isomerase: traffic cop of the RNA polymerase II transcription cycle.

Authors:  Steven D Hanes
Journal:  Biochim Biophys Acta       Date:  2014-02-12

10.  Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B.

Authors:  Xavier Hanoulle; Aurélie Badillo; Jean-Michel Wieruszeski; Dries Verdegem; Isabelle Landrieu; Ralf Bartenschlager; François Penin; Guy Lippens
Journal:  J Biol Chem       Date:  2009-03-18       Impact factor: 5.157
  10 in total

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