Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Levodopa toxicity in foetal rat midbrain neurones in culture: modulation by ascorbic acid.

Literature DB >> 8499605

Levodopa toxicity in foetal rat midbrain neurones in culture: modulation by ascorbic acid.

M A Mena¹, B Pardo, C L Paino, J G De Yebenes.

Abstract

Levodopa, a dopamine (DA) precursor administered to patients with Parkinson's disease (PD), produces at 25-200 x 10(-6) M concentrations a dose-dependent reduction of 3H-DA uptake in foetal rat midbrain cultures. Also, a decrease in the number of viable cells and tyrosine hydroxylase (TH) positive neurones, plus disruption of the overall neuritic network are observed concurrently with an elevation of quinone levels in the culture medium. Ascorbic acid (AA), which abolished the quinone overproduction, partially prevented these effects. Though levodopa neurotoxicity in vivo is as yet unproven, AA may reduce vulnerability of endogenous or grafted DA neurones in patients with PD.

Entities: Chemical Disease Species

Mesh：

Substances：
Levodopa
Ascorbic Acid

Year: 1993 PMID： 8499605 DOI： 10.1097/00001756-199304000-00025

Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837

Keyword Cloud
Cited

17 in total

1. Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms.

Authors: M A Mena; M J Casarejos; A Carazo; C L Paíno; J García de Yébenes
Journal: J Neural Transm (Vienna) Date: 1997 Impact factor: 3.575

2. delta 9-Tetrahydrocannabinol increases activity of tyrosine hydroxylase in cultured fetal mesencephalic neurons.

Authors: M L Hernández; L García-Gil; F Berrendero; J A Ramos; J J Fernández-Ruiz
Journal: J Mol Neurosci Date: 1997-04 Impact factor: 3.444

3. Synergistic effect of alpha-dihydroergocryptine and L-dopa or dopamine on dopaminergic neurons in primary culture.

Authors: G Gille; K Radad; H Reichmann; W-D Rausch
Journal: J Neural Transm (Vienna) Date: 2005-10-27 Impact factor: 3.575

4. Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease.

Authors: G Walkinshaw; C M Waters
Journal: J Clin Invest Date: 1995-06 Impact factor: 14.808

Levodopa toxicity in foetal rat midbrain neurones in culture: modulation by ascorbic acid.

1. Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms.

2. delta 9-Tetrahydrocannabinol increases activity of tyrosine hydroxylase in cultured fetal mesencephalic neurons.

3. Synergistic effect of alpha-dihydroergocryptine and L-dopa or dopamine on dopaminergic neurons in primary culture.

4. Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease.

Review 5. Levodopa in Parkinson's disease: neurotoxicity issue laid to rest?

Review 6. When should levodopa therapy be initiated in patients with Parkinson's disease?

7. Levodopa slows progression of Parkinson's disease: external validation by clinical trial simulation.

8. The role of 3-O-methyldopa in the side effects of L-dopa.

Review 9. The role of astroglia on the survival of dopamine neurons.

10. Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease.