Literature DB >> 8490654

Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees.

M Baron1, N F Freimer, N Risch, B Lerer, J R Alexander, R E Straub, S Asokan, K Das, A Peterson, J Amos.   

Abstract

The hypothesis that chromosomal region Xq27-28 harbours a gene for manic-depression has been a focus of interest in human genetics. X-linked inheritance of manic depressive illness has been re-examined in 3 multigeneration Israeli kindreds. Extension and re-evaluation of pedigree data, including new individuals, diagnostic follow-up, and analysis with DNA markers, shows greatly diminished support for linkage to Xq28. The peak lod scores in two of the pedigrees have dropped several lod units to clearly negative values at the RCP-F8-G6PD gene cluster. On the other hand, positive lod scores (Zmax = 2.09) are sustained in another pedigree at the same map location. None of the pedigrees show linkage to more proximal markers, including the Xq27 locus DXS98. Our analysis underscores the uncertainties in studying complex disorders.

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Year:  1993        PMID： 8490654     DOI： 10.1038/ng0193-49

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  24 in total

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Journal:  J Psychiatry Neurosci       Date:  2000-09       Impact factor: 6.186

2.  PPM-X: a new X-linked mental retardation syndrome with psychosis, pyramidal signs, and macroorchidism maps to Xq28.

Authors:  S Lindsay; M Splitt; S Edney; T P Berney; S J Knight; K E Davies; O O'Brien; M Gale; J Burn
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

Review 3.  Schizophrenia: genetic tools for unraveling the nature of a complex disorder.

Authors:  P Propping; M M Nöthen
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

4.  Linkage analysis in Rett syndrome families suggests that there may be a critical region at Xq28.

Authors:  T Webb; A Clarke; F Hanefeld; J L Pereira; L Rosenbloom; C G Woods
Journal:  J Med Genet       Date:  1998-12       Impact factor: 6.318

Review 5.  Understanding the genetic basis of mood disorders: where do we stand?

Authors:  V I Reus; N B Freimer
Journal:  Am J Hum Genet       Date:  1997-06       Impact factor: 11.025

6.  A follow-up report of a genome search for affective disorder predisposition loci in the Old Order Amish.

Authors:  M C LaBuda; M Maldonado; D Marshall; K Otten; D S Gerhard
Journal:  Am J Hum Genet       Date:  1996-12       Impact factor: 11.025

7.  A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample.

Authors:  I Pérez de Castro; J Santos; P Torres; G Visedo; J Saiz-Ruiz; C Llinares; J Fernández-Piqueras
Journal:  J Med Genet       Date:  1995-02       Impact factor: 6.318

Review 8.  Genetic epidemiologic studies of affective disorders in childhood and adolescence.

Authors:  K R Merikangas
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1993       Impact factor: 5.270

9.  Replication of genetic linkage by follow-up of previously studied pedigrees.

Authors:  E S Gershon; L R Goldin
Journal:  Am J Hum Genet       Date:  1994-04       Impact factor: 11.025

10.  Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22.

Authors:  K C Wilhelmsen; T Lynch; E Pavlou; M Higgins; T G Nygaard
Journal:  Am J Hum Genet       Date:  1994-12       Impact factor: 11.025
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