Literature DB >> 7760324

A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample.

I Pérez de Castro1, J Santos, P Torres, G Visedo, J Saiz-Ruiz, C Llinares, J Fernández-Piqueras.   

Abstract

Genetic factors play an important role in the aetiology of bipolar affective disorder (BP). So far, results of linkage studies have been largely disappointing. We have searched for a possible association between polymorphic DNA markers of two candidate genes (tyrosine hydroxylase, TH; dopamine D2 receptor gene, DRD2) and BP in a population from central Spain. Our results are consistent with the existence of a weak association between these two genes and BP, in such a way that TH and DRD2 could be considered as minor genes contributing to susceptibility.

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Year:  1995        PMID： 7760324      PMCID： PMC1050236          DOI： 10.1136/jmg.32.2.131

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  27 in total

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