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Literature DB >> 848930

Changes in superhelical density of closed circular deoxyribonucleic acid by intercalation of anti-R-plasmid drugs and primaquine.

Abstract

The following compounds, which possess anti-R-plasmid activity (Hahn and Ciak, 1976) in decreasing order, were shown by viscometric titration to change systematically the superhelical density of closed circular PM2 deoxyribonucleic acid in the manner of intercalators: ethidium bromide, quinacrine, acridine orange, quinine, chlorpromazine, chloroquine, and methylene blue. The same effect was caused by the antimalarial drug primaquine, which has not been tested for antiplasmid activity.

Entities: Chemical Species

Mesh：

Substances：

Year: 1977 PMID： 848930 PMCID： PMC351963 DOI： 10.1128/AAC.11.2.251

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

35 in total

1. The superhelix density of bacteriophage PM2 DNA, determined by a viscometric method.

Authors: E M. Smit; P Borst
Journal: FEBS Lett Date: 1971-04 Impact factor: 4.124

2. Interactions of the antibiotic, distamycin A, with native DNA and with synthetic duplex polydeoxyribonucleotides.

Authors: A K. Krey; R G. Allison; F E. Hahn
Journal: FEBS Lett Date: 1973-01-01 Impact factor: 4.124

3. INTERACTION OF THE RADICAL ION OF CHLORPROMAZINE WITH DEOXYRIBONUCLEIC ACID.

Authors: S I OHNISHI; H M MCCONNELL
Journal: J Am Chem Soc Date: 1965-05-20 Impact factor: 15.419

4. The structure of the DNA-acridine complex.

Authors: L S LERMAN
Journal: Proc Natl Acad Sci U S A Date: 1963-01-15 Impact factor: 11.205

5. Study on the binding nature of acridine orange to DNA by means of flow dichroism.

Authors: H Takesada; E Saito; H Fujita; K Suzuki; A Wada
Journal: Bull Chem Soc Jpn Date: 1970-01 Impact factor: 5.488

6. The degree of unwinding of the DNA helix by ethidium. I. Titration of twisted PM2 DNA molecules in alkaline cesium chloride density gradients.

Authors: J C Wang
Journal: J Mol Biol Date: 1974-11-15 Impact factor: 5.469

7. The interaction of closed circular DNA with intercalative dyes. I. The superhelix density of SV40 DNA in the presence and absence of dye.

Authors: W Bauer; J Vinograd
Journal: J Mol Biol Date: 1968-04-14 Impact factor: 5.469

Review 8. Studies on modes of action of chloroquine, quinacrine, and quinine and on chloroquine resistance.

Authors: F E Hahn; R L O'Brien; J Ciak; J L Allison; J G Olenick
Journal: Mil Med Date: 1966-09 Impact factor: 1.437

9. Antibacterial action of primaquine: effects in vitro on polypeptide synthesis and in vivo on ribosomes and ribosomal ribonucleic acid.

Authors: J G Olenick
Journal: Antimicrob Agents Chemother Date: 1975-12 Impact factor: 5.191