Literature DB >> 4955293

Chloroquine: mode of action.

J Ciak, F E Hahn.   

Abstract

The drug chloroquine is bactericidal for Bacillus megaterium; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine.

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Year:  1966        PMID： 4955293     DOI： 10.1126/science.151.3708.347

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

Review 1.  Antimalarial agents: mechanisms of action.

Authors:  P H Schlesinger; D J Krogstad; B L Herwaldt
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

2.  Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens.

Authors:  T F Byrd; M A Horwitz
Journal:  J Clin Invest       Date:  1991-07       Impact factor: 14.808

3.  Chloroquine-induced alterations in rat sensory ganglia cultivated in vitro. A light and electron microscope study.

Authors:  K H Tischner
Journal:  Acta Neuropathol       Date:  1972       Impact factor: 17.088

Review 4.  [Biochemistry of some parasitic helminths and protozoa and the mode of action of some antiparasitic drugs].

Authors:  H Metzger
Journal:  Z Parasitenkd       Date:  1970

5.  [Histopathologic peculiarities of the myoneuropathy caused by chloroquine diphosphate].

Authors:  G W Klinghardt
Journal:  Naturwissenschaften       Date:  1968-03

Review 6.  [Experimental principles of amyloidosis therapy].

Authors:  W Zschiesche
Journal:  Klin Wochenschr       Date:  1969-12-01

7.  Inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride.

Authors:  W C Koff; D L Peavy; V Knight
Journal:  Infect Immun       Date:  1979-03       Impact factor: 3.441

8.  Antibacterial action of primaquine: effects in vitro on polypeptide synthesis and in vivo on ribosomes and ribosomal ribonucleic acid.

Authors:  J G Olenick
Journal:  Antimicrob Agents Chemother       Date:  1975-12       Impact factor: 5.191

9.  Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy.

Authors:  Bojana Gligorijevic; Kyle Purdy; David A Elliott; Roland A Cooper; Paul D Roepe
Journal:  Mol Biochem Parasitol       Date:  2008-01-09       Impact factor: 1.759

10.  Chloroquine: its effect on leucocyte auto- and heterophagocytosis.

Authors:  C J Jones; M I Jayson
Journal:  Ann Rheum Dis       Date:  1984-04       Impact factor: 19.103
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