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Literature DB >> 8487630

Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.

Abstract

A phylogenetic analysis of sex-chromosomal zinc-finger genes (Zfx and Zfy) indicates that the genes have not evolved completely independently since their initial separation. The sequence similarities suggest gene conversion in the last exon between the duplicated Y-chromosomal genes Zfy-1 and Zfy-2 in the mouse. There are also indications of conversion (or recombination) between the X- and Y-chromosomal genes in the crab-eating fox and in the mouse. The method for estimating synonymous and nonsynonymous substitutions is modified by incorporating the substitutions in the twofold-degenerate sites in a novel way. The estimates of synonymous substitutions support the generation-time hypothesis in that the obtained rates are higher in mice (by a factor of 4.7) than in humans and higher in the Y-chromosomal genes (by a factor of 1.9) than in the X-chromosomal genes.

Entities: Gene Species

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Year: 1993 PMID： 8487630 DOI： 10.1093/oxfordjournals.molbev.a040003

Source DB: PubMed Journal: Mol Biol Evol ISSN： 0737-4038 Impact factor: 16.240

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Cited

177 in total

1. Rates of nucleotide substitution and mammalian nuclear gene evolution. Approximate and maximum-likelihood methods lead to different conclusions.

Authors: J P Bielawski; K A Dunn; Z Yang
Journal: Genetics Date: 2000-11 Impact factor: 4.562

2. Molecular evolution of the avian CHD1 genes on the Z and W sex chromosomes.

Authors: A K Fridolfsson; H Ellegren
Journal: Genetics Date: 2000-08 Impact factor: 4.562

3. Rates of nucleotide substitution in sexual and anciently asexual rotifers.

Authors: D B Mark Welch; M S Meselson
Journal: Proc Natl Acad Sci U S A Date: 2001-05-29 Impact factor: 11.205

4. Essential genes are more evolutionarily conserved than are nonessential genes in bacteria.

Authors: I King Jordan; Igor B Rogozin; Yuri I Wolf; Eugene V Koonin
Journal: Genome Res Date: 2002-06 Impact factor: 9.043

5. The problem of counting sites in the estimation of the synonymous and nonsynonymous substitution rates: implications for the correlation between the synonymous substitution rate and codon usage bias.

Authors: Nicolas Bierne; Adam Eyre-Walker
Journal: Genetics Date: 2003-11 Impact factor: 4.562

Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.

1. Rates of nucleotide substitution and mammalian nuclear gene evolution. Approximate and maximum-likelihood methods lead to different conclusions.

2. Molecular evolution of the avian CHD1 genes on the Z and W sex chromosomes.

3. Rates of nucleotide substitution in sexual and anciently asexual rotifers.

4. Essential genes are more evolutionarily conserved than are nonessential genes in bacteria.

5. The problem of counting sites in the estimation of the synonymous and nonsynonymous substitution rates: implications for the correlation between the synonymous substitution rate and codon usage bias.

6. Complex evolution of 7E olfactory receptor genes in segmental duplications.

7. Selective pressures on the olfactory receptor repertoire since the human-chimpanzee divergence.

8. Standardized phylogenetic tree: a reference to discover functional evolution.

9. Allelic polymorphism of T-cell receptor constant domains is widespread in fishes.

10. Complete genomic sequence analyses of Turnip mosaic virus basal-BR isolates from China.