Literature DB >> 8484092

Reduction of tumor necrosis factor alpha and interleukin-1 beta levels in human synovial tissue by interleukin-4 and glucocorticoid.

A Bendrups1, A Hilton, A Meager, J A Hamilton.   

Abstract

The effects of recombinant human interleukin-4 (IL-4) and the glucocorticoid, dexamethasone, on tumor necrosis factor alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) levels in cultures of rheumatoid and osteoarthritic synovial tissue were studied. Low concentrations of IL-4 and dexamethasone suppressed the levels of both cytokines in the supernatants of both types of tissue after stimulation with lipopolysaccharide (LPS); the IL-1 beta and TNF alpha levels were measured by ELISA. It is suggested that it is the monocyte/macrophage in the synovial tissues that is responsive to the inhibitors. It is proposed that glucocorticoids may act on synovial tissue in this manner in vivo and IL-4 may do so if administered intraarticularly.

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Year:  1993        PMID： 8484092     DOI： 10.1007/bf00301004

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  19 in total

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Authors:  M W ROPES; G A BENNETT; S COBB; R JACOX; R A JESSAR
Journal:  Bull Rheum Dis       Date:  1958-12

2.  Stimulation of human chondrocyte prostaglandin E2 production by recombinant human interleukin-1 and tumour necrosis factor.

Authors:  I K Campbell; D S Piccoli; J A Hamilton
Journal:  Biochim Biophys Acta       Date:  1990-03-09

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Authors:  P E Lipsky; L S Davis; J J Cush; N Oppenheimer-Marks
Journal:  Springer Semin Immunopathol       Date:  1989

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Authors:  P Miossec; M Naviliat; A Dupuy d'Angeac; J Sany; J Banchereau
Journal:  Arthritis Rheum       Date:  1990-08

5.  Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes.

Authors:  D L Cheung; P H Hart; G F Vitti; G A Whitty; J A Hamilton
Journal:  Immunology       Date:  1990-09       Impact factor: 7.397

6.  Stimulation of human synovial fibroblast DNA synthesis by recombinant human cytokines.

Authors:  D M Butler; D S Piccoli; P H Hart; J A Hamilton
Journal:  J Rheumatol       Date:  1988-10       Impact factor: 4.666

7.  Effects of tumor necrosis factor alpha and beta on resorption of human articular cartilage and production of plasminogen activator by human articular chondrocytes.

Authors:  I K Campbell; D S Piccoli; M J Roberts; K D Muirden; J A Hamilton
Journal:  Arthritis Rheum       Date:  1990-04

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Authors:  V A Danis; L M March; D S Nelson; P M Brooks
Journal:  J Rheumatol       Date:  1987-02       Impact factor: 4.666

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Authors:  M F Brown; B L Hazleman; J T Dingle; D J Dandy; A H Murley
Journal:  Ann Rheum Dis       Date:  1987-04       Impact factor: 19.103

10.  Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint.

Authors:  E R Pettipher; G A Higgs; B Henderson
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205
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  9 in total

1.  Altered leucocyte trafficking and suppressed tumour necrosis factor alpha release from peripheral blood monocytes after intra-articular glucocorticoid treatment.

Authors:  J H Steer; D T Ma; L Dusci; G Garas; K E Pedersen; D A Joyce
Journal:  Ann Rheum Dis       Date:  1998-12       Impact factor: 19.103

2.  Vitamin D-mediated calcium absorption in patients with clinically stable Crohn's disease: a pilot study.

Authors:  Meena Kumari; Natasha B Khazai; Thomas R Ziegler; Mark S Nanes; Steven A Abrams; Vin Tangpricha
Journal:  Mol Nutr Food Res       Date:  2010-08       Impact factor: 5.914

Review 3.  Current pharmacological treatment of osteoarthritis.

Authors:  F A Wollheim
Journal:  Drugs       Date:  1996       Impact factor: 9.546

4.  Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis.

Authors:  J L Funk; L A Cordaro; H Wei; J B Benjamin; D E Yocum
Journal:  J Clin Invest       Date:  1998-04-01       Impact factor: 14.808

5.  Interleukin-4 (IL-4) induces down-modulation and shedding of the p55 tumour necrosis factor receptor and inhibits TNF alpha's effect on rheumatoid synovial fibroblasts.

Authors:  D J Taylor
Journal:  Rheumatol Int       Date:  1994       Impact factor: 2.631

6.  Serum IL-4, IL-10 and IL-6 levels in inflammatory arthritis.

Authors:  F M Cicuttini; K A Byron; D Maher; A M Wootton; K D Muirden; J A Hamilton
Journal:  Rheumatol Int       Date:  1995       Impact factor: 2.631

7.  Recent Advances in Clinical Translation of Intra-Articular Osteoarthritis Drug Delivery Systems.

Authors:  Carlisle R DeJulius; Shubham Gulati; Karen A Hasty; Leslie J Crofford; Craig L Duvall
Journal:  Adv Ther (Weinh)       Date:  2020-09-28

8.  Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines.

Authors:  Yihong C S Lu; Christopher H Evans; Alan J Grodzinsky
Journal:  Arthritis Res Ther       Date:  2011-09-02       Impact factor: 5.156

9.  The Role of Interleukin-4 and Interleukin-10 in Osteoarthritic Joint Disease: A Systematic Narrative Review.

Authors:  E M van Helvoort; E van der Heijden; J A G van Roon; N Eijkelkamp; S C Mastbergen
Journal:  Cartilage       Date:  2022 Apr-Jun       Impact factor: 3.117
  9 in total

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