Literature DB >> 3496055

Production of cartilage degrading activity by human synovial tissues.

M F Brown, B L Hazleman, J T Dingle, D J Dandy, A H Murley.   

Abstract

Human synovial tissues have been assayed for the production of cartilage degrading activity (CDA). This activity is thought to be homologous with catabolin/interleukin 1 (IL1) produced by porcine synovium and leucocytes and by human leucocytes. The CDA of 26 rheumatoid (RA) and 41 non-rheumatoid synovia was measured on a dry weight basis. The rheumatoid synovia showed a threefold increase in activity over the non-rheumatoid, but there was no significant overall difference on a deoxyribonucleic acid (DNA) basis. The rheumatoid synovia appeared to consist of two populations; in over half the samples CDA was not related to cellularity, but eight patients had a high CDA and a high cellularity.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3496055      PMCID： PMC1002127          DOI： 10.1136/ard.46.4.319

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  15 in total

1.  Fluorimetric determination of DNA in papain digests of cartilage, using ethidium bromide.

Authors:  P M Royce; D A Lowther
Journal:  Connect Tissue Res       Date:  1979       Impact factor: 3.417

2.  Synovial collagenase: its presence in culture from joint disease of diverse etiology.

Authors:  E D Harris; G L Cohen; S M Krane
Journal:  Arthritis Rheum       Date:  1969-04

3.  A cartilage catabolic factor from synovium.

Authors:  J T Dingle; J Saklatvala; R Hembry; J Tyler; H B Fell; R Jubb
Journal:  Biochem J       Date:  1979-10-15       Impact factor: 3.857

4.  Identification of catabolin, a protein fro synovium which induces degradation of cartilage in organ culture.

Authors:  J Saklatvala; J T Dingle
Journal:  Biochem Biophys Res Commun       Date:  1980-10-16       Impact factor: 3.575

5.  Heberden oration 1978. Recent studies on the control of joint damage: the contribution of the Strangeways Research Laboratory.

Authors:  J T Dingle
Journal:  Ann Rheum Dis       Date:  1979-06       Impact factor: 19.103

6.  The effect of synovial tissue on the breakdown of articular cartilage in organ culture.

Authors:  H B Fell; R W Jubb
Journal:  Arthritis Rheum       Date:  1977 Sep-Oct

7.  Prostaglandin synthesis by rheumatoid synovium and its stimulation by colchicine.

Authors:  D R Robinson; H Smith; M B McGuire; L Levine
Journal:  Prostaglandins       Date:  1975-07

8.  Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.

Authors:  J Saklatvala; L M Pilsworth; S J Sarsfield; J Gavrilovic; J K Heath
Journal:  Biochem J       Date:  1984-12-01       Impact factor: 3.857

9.  Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules.

Authors:  J A Tyler
Journal:  Biochem J       Date:  1985-05-01       Impact factor: 3.857

10.  Effects of antirheumatoid drugs on the production and action of porcine catabolin.

Authors:  H Sheppeard; L M Pilsworth; B Hazleman; J T Dingle
Journal:  Ann Rheum Dis       Date:  1982-10       Impact factor: 19.103
View more
  3 in total

1.  In vivo studies of articular tissue damage mediated by catabolin/interleukin 1.

Authors:  J T Dingle; D P Page Thomas; B King; D R Bard
Journal:  Ann Rheum Dis       Date:  1987-07       Impact factor: 19.103

2.  Reduction of tumor necrosis factor alpha and interleukin-1 beta levels in human synovial tissue by interleukin-4 and glucocorticoid.

Authors:  A Bendrups; A Hilton; A Meager; J A Hamilton
Journal:  Rheumatol Int       Date:  1993       Impact factor: 2.631

3.  Differential responses of old human cartilage explants to synovial- and mononuclear-cell factors.

Authors:  O Huber-Bruning; B Wilbrink; J E Vernooij; J W Bijlsma; W den Otter; J Huber
Journal:  Rheumatol Int       Date:  1987       Impact factor: 2.631
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.