Literature DB >> 8481102

Investigation of possible metabolism of pigment yellow 17, a 3,3'-dichlorobenzidine-based pigment, after inhalation exposure in rats.

T Hofmann1, D Schmidt.   

Abstract

Rats were exposed by inhalation to the technically highest administrable concentration of 230 mg Pigment Yellow 17/m3 air for 4 h. Inhalability of the dust was guaranteed by a mass-median aerodynamic diameter of 1.0-1.1 microns. For 14 days after exposure, urine and serum samples were analysed for 3,3'-dichlorobenzidine, the parent carcinogenic amine of the test compound. No 3,3'-dichlorobenzidine could be detected either in urine or blood, the detection limit being 5 ng/ml for both media. Based on the results of this study there is no evidence for metabolic cleavage of Pigment Yellow 17 to 3,3'-dichlorobenzidine in the rat.

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Year:  1993        PMID： 8481102     DOI： 10.1007/bf01973685

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  10 in total

1.  Experimental neoplasia in rats from oral administration of 3,3'-dichlorobenzidine, 4,4'-methylene-bis-bis(2-chloroaniline), and 4,4'-methylene-bis(2-methylaniline).

Authors:  E F Stula; H Sherman; J A Zapp; J W Clayton
Journal:  Toxicol Appl Pharmacol       Date:  1975-01       Impact factor: 4.219

2.  [3, 3'-Dichlorobenzidine as a blastomogenic agent].

Authors:  G B PLUSS
Journal:  Vopr Onkol       Date:  1959

3.  Metabolism of bisazobiphenyl dyes derived from benzidine, 3,3'-dimethylbenzidine or 3,3'-dimethoxybenzidine to carcinogenic aromatic amines in the dog and rat.

Authors:  R K Lynn; D W Donielson; A M Ilias; J M Kennish; K Wong; H B Matthews
Journal:  Toxicol Appl Pharmacol       Date:  1980-11       Impact factor: 4.219

4.  Chromatographic assays for traces of potentially carcinogenic metabolites of two azo dyes, Direct Red 2 and Direct Blue 15, in rat, hamster and human urine.

Authors:  C R Nony; J R Althaus; M C Bowman
Journal:  J Anal Toxicol       Date:  1983 Jan-Feb       Impact factor: 3.367

5.  Liver and urinary bladder tumors in dogs from 3,3'-dichlorobenzidine.

Authors:  E F Stula; J R Barnes; H Sherman; C F Reinhardt; J A Zapp
Journal:  J Environ Pathol Toxicol       Date:  1978 Mar-Apr

6.  Metabolism of azo dyes derived from benzidine, 3,3'-dimethyl-benzidine and 3,3'-dimethoxybenzidine to potentially carcinogenic aromatic amines by intestinal bacteria.

Authors:  C E Cerniglia; J P Freeman; W Franklin; L D Pack
Journal:  Carcinogenesis       Date:  1982       Impact factor: 4.944

7.  Metabolism of a dimethylbenzidine-based dye in rats and hamsters as determined by analysis of the urine for potentially carcinogenic aromatic amines.

Authors:  C R Nony; J L Martin; M C Bowman
Journal:  J Anal Toxicol       Date:  1983 Jan-Feb       Impact factor: 3.367

8.  Thirteen-week subchronic toxicity studies of Direct Blue 6, Direct Black 38, and Direct Brown 95 dyes.

Authors:  J F Robens; G S Dill; J M Ward; J R Joiner; R A Griesemer; J F Douglas
Journal:  Toxicol Appl Pharmacol       Date:  1980-07       Impact factor: 4.219

9.  The release of 4,4'-diaminobiphenyls from azodyes in the rat.

Authors:  J C Kennelly; P J Hertzog; C N Martin
Journal:  Carcinogenesis       Date:  1982       Impact factor: 4.944

10.  Metabolism and distribution of two 14C-benzidine-congener-based dyes in rats as determined by GC, HPLC, and radioassays.

Authors:  M C Bowman; W L Oller; C R Nony; K L Rowland; S M Billedeau
Journal:  J Anal Toxicol       Date:  1982 Jul-Aug       Impact factor: 3.367
  10 in total

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