Literature DB >> 8476427

Midkine, a novel neurotrophic factor, is present in senile plaques of Alzheimer disease.

O Yasuhara1, H Muramatsu, S U Kim, T Muramatsu, H Maruta, P L McGeer.   

Abstract

An affinity purified antibody specific for midkine (MK) stained senile plaques in the brain of Alzheimer disease (AD) patients. After formic acid treatment, plaque staining was dramatically enhanced, and almost all beta-amyloid protein (BAP) deposits were also immunoreactive for MK. MK-immunoreactivity was not observed in normal cellular components nor in other pathological lesions including tangles in AD brain. Control brain sections were not immunoreactive for MK. The presence of MK in AD brain but not in control brain was confirmed by Western blotting. MK appears to be involved in the pathological process leading to senile plaque formation.

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Year:  1993        PMID： 8476427     DOI： 10.1006/bbrc.1993.1406

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  24 in total

1.  Problems associated with biological markers of Alzheimer's disease.

Authors:  H J Frey; K M Mattila; M A Korolainen; T Pirttilä
Journal:  Neurochem Res       Date:  2005-12       Impact factor: 3.996

2.  Neointima formation in a restenosis model is suppressed in midkine-deficient mice.

Authors:  M Horiba; K Kadomatsu; E Nakamura; H Muramatsu; S Ikematsu; S Sakuma; K Hayashi; Y Yuzawa; S Matsuo; M Kuzuya; T Kaname; M Hirai; H Saito; T Muramatsu
Journal:  J Clin Invest       Date:  2000-02       Impact factor: 14.808

3.  Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders.

Authors:  Miryam Pastor; Rosalía Fernández-Calle; Bruno Di Geronimo; Marta Vicente-Rodríguez; José María Zapico; Esther Gramage; Claire Coderch; Carmen Pérez-García; Amy W Lasek; Leonor Puchades-Carrasco; Antonio Pineda-Lucena; Beatriz de Pascual-Teresa; Gonzalo Herradón; Ana Ramos
Journal:  Eur J Med Chem       Date:  2017-11-28       Impact factor: 6.514

Review 4.  Targeting midkine and pleiotrophin signalling pathways in addiction and neurodegenerative disorders: recent progress and perspectives.

Authors:  G Herradón; C Pérez-García
Journal:  Br J Pharmacol       Date:  2014-02       Impact factor: 8.739

5.  Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1.

Authors:  Kazuma Sakamoto; Guojun Bu; Sen Chen; Yoshifumi Takei; Kenji Hibi; Yasuhiro Kodera; Lynn M McCormick; Akimasa Nakao; Masaharu Noda; Takashi Muramatsu; Kenji Kadomatsu
Journal:  J Biol Chem       Date:  2011-01-05       Impact factor: 5.157

6.  Mice with genetic deletion of the heparin-binding growth factor midkine exhibit early preclinical features of Parkinson's disease.

Authors:  Rui D S Prediger; Argelia E Rojas-Mayorquin; Aderbal S Aguiar; Caroline Chevarin; Raymond Mongeau; Michel Hamon; Laurence Lanfumey; Elaine Del Bel; Hisako Muramatsu; José Courty; Rita Raisman-Vozari
Journal:  J Neural Transm (Vienna)       Date:  2011-02-08       Impact factor: 3.575

7.  Pick's disease immunohistochemistry: new alterations and Alzheimer's disease comparisons.

Authors:  O Yasuhara; A Matsuo; I Tooyama; H Kimura; E G McGeer; P L McGeer
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

8.  Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus.

Authors:  Yun B Kim; Jae K Ryu; Hong J Lee; In J Lim; Dongsun Park; Min C Lee; Seung U Kim
Journal:  BMC Neurosci       Date:  2010-03-26       Impact factor: 3.288

9.  Midkine secretion protects Hep3B cells from cadmium induced cellular damage.

Authors:  Nuray Yazihan; Haluk Ataoglu; Ethem Akcil; Burcu Yener; Bulent Salman; Cengiz Aydin
Journal:  World J Gastroenterol       Date:  2008-01-07       Impact factor: 5.742

10.  The advances of Midkine with peripheral invasion in pancreatic cancer.

Authors:  Jun Yao; Wen-Yao Li; She-Gan Gao
Journal:  Am J Cancer Res       Date:  2015-08-15       Impact factor: 6.166
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