Literature DB >> 8476206

Glyoxalase activities in human tumour cell lines in vitro.

F Ayoub1, M Zaman, P Thornalley, J Masters.   

Abstract

The activities of glyoxalase I (EC 4.4.1.5) and glyoxalase II (EC 3.1.2.6) were measured in 3 human non-malignant and 28 tumour cell lines. The activity of glyoxalase I was in the range 321-8751 mUnits/mg of protein. The glyoxalase I/glyoxalase II activity ratio was in the range 7-147; glyoxalase I activity was always markedly greater than glyoxalase activity. There was no significant difference between glyoxalase activities in non-malignant and tumour cell lines. The activity of glyoxalase I was within and above the range found in normal human tissues and the activity of glyoxalase II was within the range and below that found in normal human tissues.

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Year:  1993        PMID： 8476206

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  10 in total

1.  Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle.

Authors:  Jacob T Mey; Brian K Blackburn; Edwin R Miranda; Alec B Chaves; Joan Briller; Marcelo G Bonini; Jacob M Haus
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2017-10-18       Impact factor: 3.619

Review 2.  Metabolic Shades of S-D-Lactoylglutathione.

Authors:  Miklós Péter Kalapos; Cinzia Antognelli; Lidia de Bari
Journal:  Antioxidants (Basel)       Date:  2022-05-20

3.  Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function.

Authors:  A V Rawlings; A Davies; M Carlomusto; S Pillai; K Zhang; R Kosturko; P Verdejo; C Feinberg; L Nguyen; P Chandar
Journal:  Arch Dermatol Res       Date:  1996-06       Impact factor: 3.017

4.  Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation.

Authors:  Gerd Birkenmeier; Christin Stegemann; Ralf Hoffmann; Robert Günther; Klaus Huse; Claudia Birkemeyer
Journal:  PLoS One       Date:  2010-04-29       Impact factor: 3.240

5.  Glyoxalase I in detoxification: studies using a glyoxalase I transfectant cell line.

Authors:  S Ranganathan; E S Walsh; K D Tew
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857

6.  Reduced ovarian glyoxalase-I activity by dietary glycotoxins and androgen excess: a causative link to polycystic ovarian syndrome.

Authors:  Eleni Kandaraki; Antonis Chatzigeorgiou; Christina Piperi; Eleni Palioura; Sotiria Palimeri; Penelope Korkolopoulou; Michael Koutsilieris; Athanasios G Papavassiliou
Journal:  Mol Med       Date:  2012-10-24       Impact factor: 6.354

Review 7.  Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease.

Authors:  Paul J Thornalley
Journal:  Drug Metabol Drug Interact       Date:  2008

8.  Glycerophosphoglycerol, Beta-alanine, and pantothenic Acid as metabolic companions of glycolytic activity and cell migration in breast cancer cell lines.

Authors:  Antje Hutschenreuther; Gerd Birkenmeier; Marina Bigl; Knut Krohn; Claudia Birkemeyer
Journal:  Metabolites       Date:  2013-11-27

9.  Modulation of GLO1 Expression Affects Malignant Properties of Cells.

Authors:  Antje Hutschenreuther; Marina Bigl; Nasr Y A Hemdan; Tewodros Debebe; Frank Gaunitz; Gerd Birkenmeier
Journal:  Int J Mol Sci       Date:  2016-12-18       Impact factor: 5.923

Review 10.  Glyoxalases in Urological Malignancies.

Authors:  Cinzia Antognelli; Vincenzo Nicola Talesa
Journal:  Int J Mol Sci       Date:  2018-01-31       Impact factor: 5.923
  10 in total

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