Literature DB >> 18533367

Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease.

Paul J Thornalley1.   

Abstract

Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal--physiological substrates of glyoxalase 1--is potentially damaging to the proteome, genome and lipidome. Glyoxalase 1 suppresses glycation by these alpha-oxoaldehyde metabolites and thereby represents part of the enzymatic defence against glycation. Albert Szent-Györgyi pioneered and struggled to understand the physiological function of methylglyoxal and the glyoxalase system. We now appreciate that glyoxalase 1 protects against dicarbonyl modifications of the proteome, genome and lipome. Latest research suggests there are functional modifications of this process--implying a role in cell signalling, ageing and disease.

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Year:  2008        PMID： 18533367      PMCID： PMC2649415          DOI： 10.1515/dmdi.2008.23.1-2.125

Source DB:  PubMed          Journal:  Drug Metabol Drug Interact        ISSN： 0792-5077


  101 in total

1.  The purification and characterization of liver glyoxalase I from normal mice and from mice bearing a lymphosarcoma.

Authors:  R A Strzinek; V E Scholes; S J Norton
Journal:  Cancer Res       Date:  1972-11       Impact factor: 12.701

2.  32P-Postlabeling analysis of a DNA adduct, an N2-acetyl derivative of guanine, formed in vitro by methylglyoxal and hydrogen peroxide in combination.

Authors:  A Tada; K Wakabayashi; Y Totsuka; T Sugimura; K Tsuji; H Nukaya
Journal:  Mutat Res       Date:  1996-04-13       Impact factor: 2.433

Review 3.  Molecular and biochemical features of poly (ADP-ribose) metabolism.

Authors:  D Lautier; J Lagueux; J Thibodeau; L Ménard; G G Poirier
Journal:  Mol Cell Biochem       Date:  1993-05-26       Impact factor: 3.396

Review 4.  Metabolism of methylglyoxal in microorganisms.

Authors:  R A Cooper
Journal:  Annu Rev Microbiol       Date:  1984       Impact factor: 15.500

5.  Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo.

Authors:  B S Szwergold; S Howell; P J Beisswenger
Journal:  Diabetes       Date:  2001-09       Impact factor: 9.461

6.  High-performance liquid chromatographic-fluorometric determination of glyoxal, methylglyoxal, and diacetyl in urine by prederivatization to pteridinic rings.

Authors:  A Espinosa-Mansilla; I Durán-Merás; F Salinas
Journal:  Anal Biochem       Date:  1998-01-15       Impact factor: 3.365

7.  Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine.

Authors:  Roya Babaei-Jadidi; Nikolaos Karachalias; Naila Ahmed; Sinan Battah; Paul J Thornalley
Journal:  Diabetes       Date:  2003-08       Impact factor: 9.461

8.  Inhibition of proliferation of human leukaemia 60 cells by diethyl esters of glyoxalase inhibitors in vitro.

Authors:  T W Lo; P J Thornalley
Journal:  Biochem Pharmacol       Date:  1992-12-15       Impact factor: 5.858

9.  Effect of methylglyoxal on human leukaemia 60 cell growth: modification of DNA G1 growth arrest and induction of apoptosis.

Authors:  Y Kang; L G Edwards; P J Thornalley
Journal:  Leuk Res       Date:  1996-05       Impact factor: 3.156

10.  Role for glyoxalase I in Alzheimer's disease.

Authors:  Feng Chen; M Axel Wollmer; Frederic Hoerndli; Gerald Münch; Björn Kuhla; Evgeny I Rogaev; Magdalini Tsolaki; Andreas Papassotiropoulos; Jürgen Götz
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-05       Impact factor: 11.205
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  133 in total

1.  Characterisation of glyoxalase I in a streptozocin-induced mouse model of diabetes with painful and insensate neuropathy.

Authors:  M M Jack; J M Ryals; D E Wright
Journal:  Diabetologia       Date:  2011-06-03       Impact factor: 10.122

Review 2.  Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy.

Authors:  Megan Jack; Douglas Wright
Journal:  Transl Res       Date:  2012-01-10       Impact factor: 7.012

3.  Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage.

Authors:  Lorena Arranz; Alba Naudí; Mónica De la Fuente; Reinald Pamplona
Journal:  Age (Dordr)       Date:  2012-02-25

4.  Exploring post-translational arginine modification using chemically synthesized methylglyoxal hydroimidazolones.

Authors:  Tina Wang; Rendy Kartika; David A Spiegel
Journal:  J Am Chem Soc       Date:  2012-05-16       Impact factor: 15.419

5.  Glyoxalase I retards renal senescence.

Authors:  Yoichiro Ikeda; Reiko Inagi; Toshio Miyata; Ryoji Nagai; Makoto Arai; Mitsuhiro Miyashita; Masanari Itokawa; Toshiro Fujita; Masaomi Nangaku
Journal:  Am J Pathol       Date:  2011-10-12       Impact factor: 4.307

6.  Malonyldialdehyde and glyoxal act differently on low-density lipoproteins and endotheliocytes.

Authors:  Elena M Kumskova; Olga A Antonova; Sergey A Balashov; Alla K Tikhaze; Arthur M Melkumyants; Vadim Z Lankin
Journal:  Mol Cell Biochem       Date:  2014-07-27       Impact factor: 3.396

7.  Myoglobin-H2O2 catalyzes the oxidation of β-ketoacids to α-dicarbonyls: mechanism and implications in ketosis.

Authors:  Douglas Ganini; Marcelo Christoff; Marilyn Ehrenshaft; Maria B Kadiiska; Ronald P Mason; Etelvino J H Bechara
Journal:  Free Radic Biol Med       Date:  2011-05-08       Impact factor: 7.376

8.  Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo.

Authors:  Cecilia Nigro; Gregory A Raciti; Alessia Leone; Thomas H Fleming; Michele Longo; Immacolata Prevenzano; Francesca Fiory; Paola Mirra; Vittoria D'Esposito; Luca Ulianich; Peter P Nawroth; Pietro Formisano; Francesco Beguinot; Claudia Miele
Journal:  Diabetologia       Date:  2014-04-24       Impact factor: 10.122

9.  NemR is a bleach-sensing transcription factor.

Authors:  Michael J Gray; Wei-Yun Wholey; Benjamin W Parker; Minwook Kim; Ursula Jakob
Journal:  J Biol Chem       Date:  2013-03-27       Impact factor: 5.157

10.  Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1.

Authors:  Weijing Cai; Maya Ramdas; Li Zhu; Xue Chen; Gary E Striker; Helen Vlassara
Journal:  Proc Natl Acad Sci U S A       Date:  2012-08-20       Impact factor: 11.205
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