| Literature DB >> 847477 |
D R Burt, I Creese, S H Snyder.
Abstract
Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.Entities:
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Year: 1977 PMID： 847477 DOI： 10.1126/science.847477
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728