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Literature DB >> 8464913

Molecular characterization of an operon required for pertussis toxin secretion.

Abstract

Mutants of Bordetella pertussis which are defective in secretion of pertussis toxin were isolated and characterized. The region of the B. pertussis chromosome identified by mutagenesis as playing a role in transport of pertussis toxin was sequenced. Analysis of this region revealed eight open reading frames, seven of which predict a protein exhibiting homology with one of the VirB proteins of Agrobacterium tumefaciens, which are involved in the transport of the T-DNA molecule across bacterial and plant membranes. Thus a set of accessory proteins are most likely involved in the secretion of pertussis toxin, and these proteins appear to be members of a family of proteins involved in the secretion of macromolecules from bacteria.

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Year: 1993 PMID： 8464913 PMCID： PMC46218 DOI： 10.1073/pnas.90.7.2970

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

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Journal: Biochemistry Date: 1982-10-26 Impact factor: 3.162

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Journal: J Biol Chem Date: 1988-04-25 Impact factor: 5.157

132 in total

1. Modulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by cag PAI encoded VirD4 homologue.

Authors: J E Crabtree; D Kersulyte; S D Li; I J Lindley; D E Berg
Journal: J Clin Pathol Date: 1999-09 Impact factor: 3.411

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Authors: K A Craig-Mylius; A A Weiss
Journal: Antimicrob Agents Chemother Date: 2000-05 Impact factor: 5.191

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Authors: K M Farizo; T Huang; D L Burns
Journal: Infect Immun Date: 2000-07 Impact factor: 3.441

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Authors: P J Planet; S C Kachlany; R DeSalle; D H Figurski
Journal: Proc Natl Acad Sci U S A Date: 2001-02-27 Impact factor: 11.205

5. Genes for the type IV secretion system in an intracellular symbiont, Wolbachia, a causative agent of various sexual alterations in arthropods.

Authors: S Masui; T Sasaki; H Ishikawa
Journal: J Bacteriol Date: 2000-11 Impact factor: 3.490

6. Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea.

Authors: S C Kachlany; P J Planet; M K Bhattacharjee; E Kollia; R DeSalle; D H Fine; D H Figurski
Journal: J Bacteriol Date: 2000-11 Impact factor: 3.490

7. DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis.

Authors: Trevor H Stenson; Alison A Weiss
Journal: Infect Immun Date: 2002-05 Impact factor: 3.441

8. Membrane localization of the S1 subunit of pertussis toxin in Bordetella pertussis and implications for pertussis toxin secretion.

Authors: Karen M Farizo; Stefanie Fiddner; Anissa M Cheung; Drusilla L Burns
Journal: Infect Immun Date: 2002-03 Impact factor: 3.441

9. The PtlE protein of Bordetella pertussis has peptidoglycanase activity required for Ptl-mediated pertussis toxin secretion.

Authors: Amy A Rambow-Larsen; Alison A Weiss
Journal: J Bacteriol Date: 2002-06 Impact factor: 3.490

10. Peptidoglycan Recognition Protein 4 Suppresses Early Inflammatory Responses to Bordetella pertussis and Contributes to Sphingosine-1-Phosphate Receptor Agonist-Mediated Disease Attenuation.

Authors: Ciaran Skerry; William E Goldman; Nicholas H Carbonetti
Journal: Infect Immun Date: 2019-01-24 Impact factor: 3.441