| Literature DB >> 8463553 |
R Poggioli1, E Rasori, A Bertolini.
Abstract
The most typical signs (stretchings, yawnings, penile erections, excessive grooming) of the behavioral syndrome induced in rats by the intracerebroventricular administration of ACTH- (1-24) (4 micrograms/rat) were dose-dependently antagonized by the intraperitoneal injection of the selective Ca++ channel inhibitor, nicardipine (dose range: 0.1-1 mg/kg). These data suggest that the influx of Ca++ into target neurons is a step of key importance for the occurrence of ACTH-induced behavioral signs, and that Ca++ may play the role of second intracellular messenger for the behavioral effects of melanocortins.Entities:
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Year: 1993 PMID： 8463553 DOI： 10.1007/BF03347653
Source DB: PubMed Journal: J Endocrinol Invest ISSN： 0391-4097 Impact factor: 4.256