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Literature DB >> 226398

ACTH-induced hyperalgesia in rats.

Abstract

The injection of ACTH 1--24 into the cerebral ventricles in rats markedly reduces the reaction time in the hot-plate test and the nociception threshold in the tail-stimulation test. Morphine antagonizes and naloxone potentiates this hyperalgesic effect of ACTH. It is proposed that ACTH peptides play a physiological role in nociception.

Entities: Chemical Disease Species

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Year: 1979 PMID： 226398 DOI： 10.1007/bf01963298

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

25 in total

1. Melanotropic activity in extrahypophyseal regions of rodent brain: effect of age, hormones, and drugs.

Authors: D Rudman; R K Chawla; B S Katra
Journal: Am J Physiol Date: 1975-04

2. Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.

Authors: R Simantov; M J Kuhar; G R Uhl; S H Snyder
Journal: Proc Natl Acad Sci U S A Date: 1977-05 Impact factor: 11.205

3. Effect of peptides and amino acids on dihydromorphine binding to the opiate receptor.

Authors: L Terenius
Journal: J Pharm Pharmacol Date: 1975-06 Impact factor: 3.765

4. Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness.

Authors: F Bloom; D Segal; N Ling; R Guillemin
Journal: Science Date: 1976-11-05 Impact factor: 47.728

5. Depression of nociceptive and other neurones in the brain by iontophoretically applied met-enkephalin.

Authors: R G Hill; C M Pepper; J F Mitchell
Journal: Nature Date: 1976-08-12 Impact factor: 49.962

6. Depression of frog isolated spinal cord by morphine and antagonism by tetracosactin.

Authors: E Zimmermann; W Krivoy
Journal: Proc Soc Exp Biol Med Date: 1974-06

7. Telemetered recording of hormone effects on hippocampal neurons.

Authors: D W Pfaff; M T Silva; J M Weiss
Journal: Science Date: 1971-04-23 Impact factor: 47.728

8. Naloxone effects on a nociceptive response of hypophysectomized and adrenalectomized mice.

Authors: P Grevert; E R Baizman; A Goldstein
Journal: Life Sci Date: 1978-08-21 Impact factor: 5.037

9. Common precursor to corticotropins and endorphins.

Authors: R E Mains; B A Eipper; N Ling
Journal: Proc Natl Acad Sci U S A Date: 1977-07 Impact factor: 11.205

10. Kinetic parameters of narcotic agonists and antagonists, with particular reference to N-allylnoroxymorphone (naloxone).

Authors: H W Kosterlitz; A J Watt
Journal: Br J Pharmacol Chemother Date: 1968-06

7 in total

Review 1. The role of hypothalamo-hypophyseal-adrenocortical system hormones in controlling pain sensitivity.

Authors: N I Yarushkina
Journal: Neurosci Behav Physiol Date: 2008-09-18

Review 2. Synaptic changes induced by melanocortin signalling.

Authors: Vanni Caruso; Malin C Lagerström; Pawel K Olszewski; Robert Fredriksson; Helgi B Schiöth
Journal: Nat Rev Neurosci Date: 2014-02 Impact factor: 34.870

3. Antagonism of the melanocortin system reduces cold and mechanical allodynia in mononeuropathic rats.

Authors: D H Vrinten; W H Gispen; G J Groen; R A Adan
Journal: J Neurosci Date: 2000-11-01 Impact factor: 6.167

4. Antagonism of the anticonflict effects of chlordiazepoxide by beta-carboline carboxylic acid ethyl ester, Ro 15-1788 and ACTH(4--10).

Authors: S V Vellucci; R A Webster
Journal: Psychopharmacology (Berl) Date: 1982 Impact factor: 4.530