Literature DB >> 8461046

Plasmodium falciparum: effects of amantadine, an antiviral, on chloroquine-resistant and -sensitive parasites in vitro and its influence on chloroquine activity.

S G Evans1, I Havlik.   

Abstract

The lysosomotropic nature of amantadine suggested potential as an antimalarial. Sensitivity tests to amantadine hydrochloride alone and in combination with chloroquine were carried out in 96-well microtitre plates using the tritiated hypoxanthine uptake method to measure parasite growth. Amantadine alone has antimalarial activity. Amantadine is more potent against chloroquine-resistant strains. Combinations of amantadine and chloroquine result in slight synergy in both resistant and sensitive strains.

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Year:  1993        PMID： 8461046     DOI： 10.1016/0006-2952(93)90264-w

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  8 in total

Review 1.  The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Authors:  Lukas Wanka; Khalid Iqbal; Peter R Schreiner
Journal:  Chem Rev       Date:  2013-02-25       Impact factor: 60.622

2.  Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents.

Authors:  David J Johnson; David A Fidock; Mathirut Mungthin; Viswanathan Lakshmanan; Amar Bir Singh Sidhu; Patrick G Bray; Stephen A Ward
Journal:  Mol Cell       Date:  2004-09-24       Impact factor: 17.970

3.  Identification of putative potassium channel homologues in pathogenic protozoa.

Authors:  David L Prole; Neil V Marrion
Journal:  PLoS One       Date:  2012-02-21       Impact factor: 3.240

4.  Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.

Authors:  Serena Pulcini; Henry M Staines; Andrew H Lee; Sarah H Shafik; Guillaume Bouyer; Catherine M Moore; Daniel A Daley; Matthew J Hoke; Lindsey M Altenhofen; Heather J Painter; Jianbing Mu; David J P Ferguson; Manuel Llinás; Rowena E Martin; David A Fidock; Roland A Cooper; Sanjeev Krishna
Journal:  Sci Rep       Date:  2015-09-30       Impact factor: 4.379

Review 5.  Role of Different Pfcrt and Pfmdr-1 Mutations in Conferring Resistance to Antimalaria Drugs in Plasmodium falciparum.

Authors:  Zaid O Ibraheem; R Abd Majid; S Mohd Noor; H Mohd Sedik; R Basir
Journal:  Malar Res Treat       Date:  2014-11-11

6.  A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine.

Authors:  Satish K Dhingra; Devasha Redhi; Jill M Combrinck; Tomas Yeo; John Okombo; Philipp P Henrich; Annie N Cowell; Purva Gupta; Matthew L Stegman; Jonathan M Hoke; Roland A Cooper; Elizabeth Winzeler; Sachel Mok; Timothy J Egan; David A Fidock
Journal:  mBio       Date:  2017-05-09       Impact factor: 7.867

7.  Amantadine as a drug to mitigate the effects of COVID-19.

Authors:  Gonzalo Emiliano Aranda Abreu; María Elena Hernández Aguilar; Deissy Herrera Covarrubias; Fausto Rojas Durán
Journal:  Med Hypotheses       Date:  2020-04-25       Impact factor: 1.538

8.  Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter.

Authors:  Sashika N Richards; Megan N Nash; Eileen S Baker; Michael W Webster; Adele M Lehane; Sarah H Shafik; Rowena E Martin
Journal:  PLoS Pathog       Date:  2016-07-21       Impact factor: 6.823
  8 in total

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