Literature DB >> 8460639

A breast-ovarian cancer susceptibility gene maps to chromosome 17q21.

J Feunteun1, S A Narod, H T Lynch, P Watson, T Conway, J Lynch, J Parboosingh, P O'Connell, R White, G M Lenoir.   

Abstract

Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.

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Year:  1993        PMID： 8460639      PMCID： PMC1682073     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  10 in total

1.  Detection of linkage for heterogeneous disorders by using multipoint linkage analysis.

Authors:  M Martinez; L R Goldin
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

2.  Power of the admixture test to detect genetic heterogeneity.

Authors:  S A Narod
Journal:  Genet Epidemiol       Date:  1991       Impact factor: 2.135

3.  Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Authors:  P Margaritte; C Bonaiti-Pellie; M C King; F Clerget-Darpoux
Journal:  Am J Hum Genet       Date:  1992-06       Impact factor: 11.025

4.  Report of the Committee on Methods of Linkage Analysis and Reporting.

Authors:  P M Conneally; J H Edwards; K K Kidd; J M Lalouel; N E Morton; J Ott; R White
Journal:  Cytogenet Cell Genet       Date:  1985

5.  Familial breast-ovarian cancer locus on chromosome 17q12-q23.

Authors:  S A Narod; J Feunteun; H T Lynch; P Watson; T Conway; J Lynch; G M Lenoir
Journal:  Lancet       Date:  1991-07-13       Impact factor: 79.321

6.  Linkage of early-onset familial breast cancer to chromosome 17q21.

Authors:  J M Hall; M K Lee; B Newman; J E Morrow; L A Anderson; B Huey; M C King
Journal:  Science       Date:  1990-12-21       Impact factor: 47.728

7.  Genetic epidemiology of breast cancer and associated cancers in high-risk families. I. Segregation analysis.

Authors:  R C Go; M C King; J Bailey-Wilson; R C Elston; H T Lynch
Journal:  J Natl Cancer Inst       Date:  1983-09       Impact factor: 13.506

8.  Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors:  D F Easton; D T Bishop; D Ford; G P Crockford
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025

9.  Genetic epidemiology of breast cancer in Britain.

Authors:  L Iselius; J Slack; M Littler; N E Morton
Journal:  Ann Hum Genet       Date:  1991-05       Impact factor: 1.670

10.  Genetic analysis of breast cancer in the cancer and steroid hormone study.

Authors:  E B Claus; N Risch; W D Thompson
Journal:  Am J Hum Genet       Date:  1991-02       Impact factor: 11.025
  10 in total
  11 in total

1.  Evidence for genetic anticipation in non-Mendelian diseases.

Authors:  A D Paterson; J L Kennedy; A Petronis
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

2.  Linkage analysis of 26 Canadian breast and breast-ovarian cancer families.

Authors:  P Tonin; R Moslehi; R Green; B Rosen; D Cole; N Boyd; C Cutler; R Margolese; R Carter; B McGillivray
Journal:  Hum Genet       Date:  1995-05       Impact factor: 4.132

Review 3.  Hereditary breast cancer and family cancer syndromes.

Authors:  H T Lynch; J Lynch; T Conway; P Watson; J Feunteun; G Lenoir; S Narod; R Fitzgibbons
Journal:  World J Surg       Date:  1994 Jan-Feb       Impact factor: 3.352

4.  Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors:  D F Easton; D T Bishop; D Ford; G P Crockford
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025

5.  A common region of deletion on chromosome 17q in both sporadic and familial epithelial ovarian tumors distal to BRCA1.

Authors:  A K Godwin; L Vanderveer; D C Schultz; H T Lynch; D A Altomare; K H Buetow; M Daly; L A Getts; A Masny; N Rosenblum
Journal:  Am J Hum Genet       Date:  1994-10       Impact factor: 11.025

6.  Breast cancer and importance of zygosity determination in triplet sisters.

Authors:  H T Lynch; P Watson; T Conway; J Lynch; J Boyd
Journal:  Breast Cancer Res Treat       Date:  1995       Impact factor: 4.872

7.  A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families.

Authors:  O Serova; M Montagna; D Torchard; S A Narod; P Tonin; B Sylla; H T Lynch; J Feunteun; G M Lenoir
Journal:  Am J Hum Genet       Date:  1996-01       Impact factor: 11.025

8.  Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

Authors:  D F Easton; D Ford; D T Bishop
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

9.  An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.

Authors:  S A Narod; D Ford; P Devilee; R B Barkardottir; H T Lynch; S A Smith; B A Ponder; B L Weber; J E Garber; J M Birch
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

Review 10.  BRCA1 and BRCA2 mutations in breast and ovarian cancer syndrome: reflection on the Creighton University historical series of high risk families.

Authors:  Olga M Sinilnikova; Sylvie Mazoyer; Colette Bonnardel; Henry T Lynch; Steven A Narod; Gilbert M Lenoir
Journal:  Fam Cancer       Date:  2006       Impact factor: 2.375
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