OBJECTIVE: To determine the acute effects of smoking during pregnancy on selected characteristics of the flow velocity waveform of the uterine artery. METHODS: We studied 19 chronic smokers at a mean (+/- standard error) gestational age of 28 +/- 1 weeks. After informed consent was given, the uterine artery was located using ultrasound imaging with color flow mapping. The characteristic waveform was imaged by pulsed Doppler ultrasonography. Maternal heart rate and blood pressure and the systolic-diastolic ratio (S/D) and resistance index of the uterine artery were measured before (-10 and -1 minutes), during (+5 and +10 minutes), and after (+20 and +30 minutes) smoking two standard cigarettes in succession. RESULTS: Maternal heart rate increased 27%, systolic blood pressure increased 8%, and diastolic blood pressure increased 19% with smoking (P < .001). The uterine artery S/D and resistance index decreased from 2.33 to 2.02 and from 0.55 to 0.49, respectively (P < .001). CONCLUSION: The acute effects of smoking on maternal systemic hemodynamics probably influence the flow velocity waveform of the uterine artery and preclude any definitive interpretation of acute changes in downstream resistance.
OBJECTIVE: To determine the acute effects of smoking during pregnancy on selected characteristics of the flow velocity waveform of the uterine artery. METHODS: We studied 19 chronic smokers at a mean (+/- standard error) gestational age of 28 +/- 1 weeks. After informed consent was given, the uterine artery was located using ultrasound imaging with color flow mapping. The characteristic waveform was imaged by pulsed Doppler ultrasonography. Maternal heart rate and blood pressure and the systolic-diastolic ratio (S/D) and resistance index of the uterine artery were measured before (-10 and -1 minutes), during (+5 and +10 minutes), and after (+20 and +30 minutes) smoking two standard cigarettes in succession. RESULTS: Maternal heart rate increased 27%, systolic blood pressure increased 8%, and diastolic blood pressure increased 19% with smoking (P < .001). The uterine artery S/D and resistance index decreased from 2.33 to 2.02 and from 0.55 to 0.49, respectively (P < .001). CONCLUSION: The acute effects of smoking on maternal systemic hemodynamics probably influence the flow velocity waveform of the uterine artery and preclude any definitive interpretation of acute changes in downstream resistance.
Authors: Kjersti Aagaard-Tillery; Catherine Y Spong; Elizabeth Thom; Baha Sibai; George Wendel; Katharine Wenstrom; Philip Samuels; Hyagriv Simhan; Yoram Sorokin; Menachem Miodovnik; Paul Meis; Mary J O'Sullivan; Deborah Conway; Ronald J Wapner Journal: Obstet Gynecol Date: 2010-03 Impact factor: 7.661
Authors: Dorothy K Hatsukami; Neal L Benowitz; Stephen I Rennard; Cheryl Oncken; Stephen S Hecht Journal: Nicotine Tob Res Date: 2006-08 Impact factor: 4.244
Authors: Julia de B Machado; V M Plínio Filho; Guilherme O Petersen; José M Chatkin Journal: BMC Pregnancy Childbirth Date: 2011-03-31 Impact factor: 3.007
Authors: Devasuda Anblagan; Nia W Jones; Carolyn Costigan; Alexander J J Parker; Kirsty Allcock; Rosanne Aleong; Lucy H Coyne; Ruta Deshpande; Nick Raine-Fenning; George Bugg; Neil Roberts; Zdenka Pausova; Tomáš Paus; Penny A Gowland Journal: PLoS One Date: 2013-07-03 Impact factor: 3.240