| Literature DB >> 845871 |
I R Ager, D R Harrison, P D Kennewell, J B Taylor.
Abstract
A number of derivatives of 2-methyl-3-(o-tolyl)-4(3H)-quinazolone bearing new substituents on the 2-methyl group have been synthesized. It was established that most substitutions at this position reduce or remove the CNS depressant activity of methaqualone. From the series prepared only the 2-fluoromethyl derivative or certain isothiouronium salts, which could be hydrolyzed in vivo to the 2-mercaptomethyl derivative, showed activity of the same magnitude as methaqualone.Entities:
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Year: 1977 PMID： 845871 DOI： 10.1021/jm00213a013
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446