OBJECTIVE: To determine if preovulation endometrial thickness or pattern are related to fecundity and to use of clomiphene citrate (CC) or hMG in IUI. DESIGN: Prospective ultrasound evaluation the day of hCG after CC alone (n = 197), hMG alone (n = 49), concurrent hMG or sequential CC and hMG (n = 205), and no medications (n = 23). SETTING: Private fertility clinic. PATIENTS: Two hundred seventy-one patients undergoing 474 cycles of IUI. MAIN OUTCOME MEASURES: Endometrial thickness, pattern, per cycle fecundity, and continuing pregnancy. RESULTS: Endometrial thickness was related to fecundity and continuing pregnancy. No pregnancies occurred when thickness was < 6 mm. The continuing pregnancy rate was 12.6% when thickness was > or = 9 mm, compared with 6.9% when thickness was 6 mm to 8 mm. Endometrial pattern was unrelated to pregnancy. Average endometrial thickness was decreased when hMG and CC were used in combination (7.9 mm) compared with hMG alone (9.4 mm). Endometrial thickness was negatively related to CC dose and positively related to the day of hCG administration by ANOVA. CONCLUSIONS: Endometrial thickness the day of hCG administration is prognostic of fecundity and continuing pregnancy in cycles of ovulation induction.
OBJECTIVE: To determine if preovulation endometrial thickness or pattern are related to fecundity and to use of clomiphene citrate (CC) or hMG in IUI. DESIGN: Prospective ultrasound evaluation the day of hCG after CC alone (n = 197), hMG alone (n = 49), concurrent hMG or sequential CC and hMG (n = 205), and no medications (n = 23). SETTING: Private fertility clinic. PATIENTS: Two hundred seventy-one patients undergoing 474 cycles of IUI. MAIN OUTCOME MEASURES: Endometrial thickness, pattern, per cycle fecundity, and continuing pregnancy. RESULTS: Endometrial thickness was related to fecundity and continuing pregnancy. No pregnancies occurred when thickness was < 6 mm. The continuing pregnancy rate was 12.6% when thickness was > or = 9 mm, compared with 6.9% when thickness was 6 mm to 8 mm. Endometrial pattern was unrelated to pregnancy. Average endometrial thickness was decreased when hMG and CC were used in combination (7.9 mm) compared with hMG alone (9.4 mm). Endometrial thickness was negatively related to CC dose and positively related to the day of hCG administration by ANOVA. CONCLUSIONS: Endometrial thickness the day of hCG administration is prognostic of fecundity and continuing pregnancy in cycles of ovulation induction.
Authors: Lauren A Wise; Kenneth J Rothman; Ellen M Mikkelsen; Henrik Toft Sørensen; Anders Riis; Elizabeth E Hatch Journal: Hum Reprod Date: 2009-10-14 Impact factor: 6.918
Authors: M J Law Smith; D I Perrett; B C Jones; R E Cornwell; F R Moore; D R Feinberg; L G Boothroyd; S J Durrani; M R Stirrat; S Whiten; R M Pitman; S G Hillier Journal: Proc Biol Sci Date: 2006-01-22 Impact factor: 5.349
Authors: Grazyna Jasieńska; Anna Ziomkiewicz; Peter T Ellison; Susan F Lipson; Inger Thune Journal: Proc Biol Sci Date: 2004-06-22 Impact factor: 5.349