Literature DB >> 8454909

Immunochemotherapy of visceral leishmaniasis: a pilot trial of sequential treatment with recombinant interferon-gamma and pentavalent antimony.

G Harms1, K Zwingenberger, B Sandkamp, S Omena, C Pedrosa, J Richter, F Rosenkaimer, H Feldmeier, U Bienzle.   

Abstract

The clinical, parasitological, hematological, and serological evolution of visceral leishmaniasis in Brazilian patients was assessed during treatment with human recombinant interferon-gamma (rIFN-gamma; 0.1 mg/m2 i.m. days 1-14) followed by pentavalent antimony (Sbv; 10 mg/kg days 22-28). At day 30, 6 patients had improved, 2 had slightly improved, and 1 patient had deteriorated. IFN-gamma was well tolerated in the dose tested and may be very effective as an adjunct to conventional therapy with antimony.

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Year:  1993        PMID: 8454909     DOI: 10.1089/jir.1993.13.39

Source DB:  PubMed          Journal:  J Interferon Res        ISSN: 0197-8357


  6 in total

1.  Successful therapy of chronic, nonhealing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production.

Authors:  J Li; S Sutterwala; J P Farrell
Journal:  Infect Immun       Date:  1997-08       Impact factor: 3.441

2.  Canine visceral leishmaniasis: successful chemotherapy induces macrophage antileishmanial activity via the L-arginine nitric oxide pathway.

Authors:  I Vouldoukis; J C Drapier; A K Nüssler; Y Tselentis; O A Da Silva; M Gentilini; D M Mossalayi; L Monjour; B Dugas
Journal:  Antimicrob Agents Chemother       Date:  1996-01       Impact factor: 5.191

3.  Miltefosine (Impavido): the first oral treatment against leishmaniasis.

Authors:  H Sindermann; S L Croft; K R Engel; W Bommer; H J Eibl; C Unger; J Engel
Journal:  Med Microbiol Immunol       Date:  2003-09-26       Impact factor: 3.402

4.  Leishmania resistant to sodium stibogluconate: drug-associated macrophage-dependent killing.

Authors:  M E Ibrahim; M Hag-Ali; A M el-Hassan; T G Theander; A Kharazmi
Journal:  Parasitol Res       Date:  1994       Impact factor: 2.289

5.  Short term treatment of visceral leishmaniasis of the Old World with low dose interferon gamma and pentavalent antimony.

Authors:  J van Lunzen; P Kern; J Schmitz; J Brzoska; S Flessenkämper; M Dietrich
Journal:  Infection       Date:  1993 Nov-Dec       Impact factor: 3.553

6.  Vaccine Development Against Leishmania donovani.

Authors:  Amrita Das; Nahid Ali
Journal:  Front Immunol       Date:  2012-05-15       Impact factor: 7.561

  6 in total

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