Literature DB >> 8454632

Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype.

R Wadhwa1, S C Kaul, Y Ikawa, Y Sugimoto.   

Abstract

A novel 66-kDa protein, named p66mot-1, is identified to be associated with cellular mortality by virtue of its presence in cytosolic fractions of serially passaged mouse embryonic fibroblasts (MEF) and the mortal hybrids obtained by the fusion of mortal (MEF) and immortal (MN48-1, derivative of NIH 3T3) cells. Immortal cells lack this protein in their cytosolic fractions. cDNA cloning and homology search placed it in the heat shock protein 70 (hsp70) family. Microinjection of anti-p66 antibody to senescent MEF could transiently stimulate their cell division, which supports the cellular mortality-related function of p66mot-1.

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Year:  1993        PMID： 8454632

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  47 in total

1.  An N-terminal region of mot-2 binds to p53 in vitro.

Authors:  S C Kaul; R R Reddel; Y Mitsui; R Wadhwa
Journal:  Neoplasia       Date:  2001 Mar-Apr       Impact factor: 5.715

Review 2.  Chaperones come of age.

Authors:  Csaba Soti; Péter Csermely
Journal:  Cell Stress Chaperones       Date:  2002-04       Impact factor: 3.667

3.  Localization of mitochondrial DNA encoded cytochrome c oxidase subunits I and II in rat pancreatic zymogen granules and pituitary growth hormone granules.

Authors:  Skanda K Sadacharan; Bhag Singh; Timothy Bowes; Radhey S Gupta
Journal:  Histochem Cell Biol       Date:  2005-11-03       Impact factor: 4.304

Review 4.  On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60.

Authors:  Custer C Deocaris; Sunil C Kaul; Renu Wadhwa
Journal:  Cell Stress Chaperones       Date:  2006       Impact factor: 3.667

5.  Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) mortalin/GRP75/peptide-binding protein 74 (PBP74) and GRP94.

Authors:  S Takano; R Wadhwa; Y Mitsui; S C Kaul
Journal:  Biochem J       Date:  2001-07-15       Impact factor: 3.857

6.  Mortalin is a prognostic factor of gastric cancer with normal p53 function.

Authors:  Koji Ando; Eiji Oki; Yan Zhao; Ayae Ikawa-Yoshida; Hiroyuki Kitao; Hiroshi Saeki; Yasue Kimura; Satoshi Ida; Masaru Morita; Tetsuya Kusumoto; Yoshihiko Maehara
Journal:  Gastric Cancer       Date:  2013-07-05       Impact factor: 7.370

Review 7.  Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential.

Authors:  Amy S Lee
Journal:  Nat Rev Cancer       Date:  2014-04       Impact factor: 60.716

8.  Reactivation of protein aggregates by mortalin and Tid1--the human mitochondrial Hsp70 chaperone system.

Authors:  Ohad Iosefson; Shelly Sharon; Pierre Goloubinoff; Abdussalam Azem
Journal:  Cell Stress Chaperones       Date:  2011-08-03       Impact factor: 3.667

9.  Down-regulation of mortalin exacerbates Aβ-mediated mitochondrial fragmentation and dysfunction.

Authors:  So Jung Park; Ji Hyun Shin; Jae In Jeong; Ji Hoon Song; Yoon Kyung Jo; Eun Sung Kim; Eunjoo H Lee; Jung Jin Hwang; Eun Kyung Lee; Sun Ju Chung; Jae-Young Koh; Dong-Gyu Jo; Dong-Hyung Cho
Journal:  J Biol Chem       Date:  2013-12-09       Impact factor: 5.157

10.  Comparative proteomic analysis of kidney development-related proteins in the pig.

Authors:  Young-Joo Jeon; Jumi Kim; Jung-Il Chae
Journal:  In Vitro Cell Dev Biol Anim       Date:  2013-04-13       Impact factor: 2.416
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