| Literature DB >> 8453666 |
T Olsson1, M Bakhiet, B Höjeberg, A Ljungdahl, C Edlund, G Andersson, H P Ekre, W P Fung-Leung, T Mak, H Wigzell, U Fiszer, K Kristensson.
Abstract
T. brucei brucei released a lymphocyte triggering factor (TLTF), which triggered purified CD8+, but not CD4+, T cells to interferon gamma (IFN-gamma) mRNA expression and secretion and to [3H]thymidine incorporation. TLTF also induced mRNA for transforming growth factor beta, but not for interleukin-4. The action of this TLTF on mononuclear cell (MNC) cultures was blocked by anti-CD8 antibodies and by soluble CD8. MNCs from a mutant mouse strain lacking CD8 expression were not triggered by TLTF. IFN-gamma provides a growth stimulus for T. brucei brucei, and infected CD8- mice had much lower parasitemia and survived longer than CD8+ mice. The host-parasite interaction in experimental African trypanosomiasis thus involves parasite release of TLTF, which by binding to CD8 triggers CD8+ cells to produce the parasite growth-promoting cytokine IFN-gamma.Entities:
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Year: 1993 PMID： 8453666 DOI： 10.1016/0092-8674(93)90400-k
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582