Literature DB >> 14966556

Human African trypanosomiasis of the CNS: current issues and challenges.

Peter G E Kennedy1.   

Abstract

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS HAT has unacceptable side-effects with an overall mortality of 5%. This review discusses the issues of diagnosis and staging of CNS disease, its neuropathogenesis, and the possibility of new therapies for treating late-stage disease.

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Year:  2004        PMID： 14966556      PMCID： PMC338269          DOI： 10.1172/JCI21052

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  50 in total

1.  Sleeping sickness: new drugs from old? [corrected].

Authors:  Peter G E Kennedy; Maxwell Murray; Frank Jennings; Jean Rodgers
Journal:  Lancet       Date:  2002-05-11       Impact factor: 79.321

2.  Gambiense trypanosomiasis: frequency of, and risk factors for, failure of melarsoprol therapy.

Authors:  J Pépin; F Milord; A Khonde; T Niyonsenga; L Loko; B Mpia
Journal:  Trans R Soc Trop Med Hyg       Date:  1994 Jul-Aug       Impact factor: 2.184

Review 3.  From trypanosomes to the nervous system, from molecules to behavior: a survey, on the occasion of the 90th anniversary of Castellani's discovery of the parasites in sleeping sickness.

Authors:  M Bentivoglio; G Grassi-Zucconi; K Kristensson
Journal:  Ital J Neurol Sci       Date:  1994-03

4.  Nitric oxide and cytokine synthesis in human African trypanosomiasis.

Authors:  L MacLean; M Odiit; J M Sternberg
Journal:  J Infect Dis       Date:  2001-09-28       Impact factor: 5.226

5.  Risk factors for treatment failure after melarsoprol for Trypanosoma brucei gambiense trypanosomiasis in Uganda.

Authors:  D Legros; S Evans; F Maiso; J C Enyaru; D Mbulamberi
Journal:  Trans R Soc Trop Med Hyg       Date:  1999 Jul-Aug       Impact factor: 2.184

6.  Comparison of different DNA preparation protocols for PCR diagnosis of Human African Trypanosomosis in Côte d'Ivoire.

Authors:  P Solano; V Jamonneau; P N'Guessan; L N'Dri; N N Dje; T W Miezan; V Lejon; P Büscher; A Garcia
Journal:  Acta Trop       Date:  2002-06       Impact factor: 3.112

Review 7.  Future prospects for the chemotherapy of human trypanosomiasis. 1. Novel approaches to the chemotherapy of trypanosomiasis.

Authors:  A H Fairlamb
Journal:  Trans R Soc Trop Med Hyg       Date:  1990 Sep-Oct       Impact factor: 2.184

8.  The gene for a T lymphocyte triggering factor from African trypanosomes.

Authors:  T Vaidya; M Bakhiet; K L Hill; T Olsson; K Kristensson; J E Donelson
Journal:  J Exp Med       Date:  1997-08-04       Impact factor: 14.307

9.  Immune complexes in serum and in cerebrospinal fluid in African trypanosomiasis. Correlation with polyclonal B cell activation and with intracerebral immunoglobulin synthesis.

Authors:  P H Lambert; M Berney; G Kazyumba
Journal:  J Clin Invest       Date:  1981-01       Impact factor: 14.808

10.  Stage determination and therapeutic decision in human African trypanosomiasis: value of polymerase chain reaction and immunoglobulin M quantification on the cerebrospinal fluid of sleeping sickness patients in Côte d'Ivoire.

Authors:  V Jamonneau; P Solano; A Garcia; V Lejon; N Djé; T W Miezan; P N'Guessan; G Cuny; P Büscher
Journal:  Trop Med Int Health       Date:  2003-07       Impact factor: 2.622
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  97 in total

1.  Novel biomarkers for late-stage human African trypanosomiasis--the search goes on.

Authors:  Peter G E Kennedy
Journal:  Am J Trop Med Hyg       Date:  2010-06       Impact factor: 2.345

2.  Discovery and verification of osteopontin and Beta-2-microglobulin as promising markers for staging human African trypanosomiasis.

Authors:  Natalia Tiberti; Alexandre Hainard; Veerle Lejon; Xavier Robin; Dieudonné Mumba Ngoyi; Natacha Turck; Enock Matovu; John Enyaru; Joseph Mathu Ndung'u; Alexander Scherl; Loïc Dayon; Jean-Charles Sanchez
Journal:  Mol Cell Proteomics       Date:  2010-08-19       Impact factor: 5.911

3.  Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.

Authors:  S Radhika Prathalingham; Shane R Wilkinson; David Horn; John M Kelly
Journal:  Antimicrob Agents Chemother       Date:  2006-12-04       Impact factor: 5.191

4.  Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease.

Authors:  Olga V Nikolskaia; Ana Paula C de A Lima; Yuri V Kim; John D Lonsdale-Eccles; Toshihide Fukuma; Julio Scharfstein; Dennis J Grab
Journal:  J Clin Invest       Date:  2006-09-21       Impact factor: 14.808

5.  African Trypanosomiasis: Changing Epidemiology and Consequences.

Authors:  Jean-Paul Chretien; Bonnie L Smoak
Journal:  Curr Infect Dis Rep       Date:  2005-01       Impact factor: 3.725

Review 6.  Parasitic central nervous system infections in immunocompromised hosts: malaria, microsporidiosis, leishmaniasis, and African trypanosomiasis.

Authors:  Melanie Walker; James G Kublin; Joseph R Zunt
Journal:  Clin Infect Dis       Date:  2005-11-23       Impact factor: 9.079

7.  Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture.

Authors:  Hiroshi Kitani; Jan Naessens; Masanori Kubo; Yoshio Nakamura; Fuad Iraqi; John Gibson; Minoru Yamakawa
Journal:  Parasitol Res       Date:  2009-03-24       Impact factor: 2.289

8.  Evaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In Vitro.

Authors:  Karl A Werbovetz; Edward S Riccio; Anna Furimsky; Julian V Richard; Shanshan He; Lalitha Iyer; Jon Mirsalis
Journal:  Int J Toxicol       Date:  2014-05-12       Impact factor: 2.032

9.  Human African Trypanosomiasis Encephalitis in the United States: Serial Magnetic Resonance Imaging.

Authors:  Mary Carter Denny; Leon L Lai; Robert Laureno
Journal:  Neurohospitalist       Date:  2016-03-24

10.  Structural and Functional Highlights of Vacuolar Soluble Protein 1 from Pathogen Trypanosoma brucei brucei.

Authors:  Abhishek Jamwal; Adam R Round; Ludovic Bannwarth; Catherine Venien-Bryan; Hassan Belrhali; Manickam Yogavel; Amit Sharma
Journal:  J Biol Chem       Date:  2015-10-22       Impact factor: 5.157
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