Literature DB >> 8453222

Clinical experience with a hypotonic oral rehydration solution in acute diarrhoea.

T Rautanen1, S el-Radhi, T Vesikari.   

Abstract

A hypotonic oral rehydration salts (ORS) solution with total osmolality of 224 mosmol/l was compared in an open clinical trial with an isotonic (osmolality 304 mosmol/l) ORS solution for the treatment of dehydration due to acute diarrhoea. Both ORS solutions had the same electrolyte composition with a Na+ concentration of 60 mmol/l. Children given the hypotonic ORS solution (n = 103) passed significantly fewer diarrhoeal stools, and their diarrhoea and hospital stay were shorter than those of children given the isotonic ORS solution (n = 135). We conclude that hypotonic ORS ("light" ORS) has clinical advantages over the standard ORS currently used in Finland.

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Year:  1993        PMID： 8453222     DOI： 10.1111/j.1651-2227.1993.tb12516.x

Source DB:  PubMed          Journal:  Acta Paediatr        ISSN： 0803-5253            Impact factor:   2.299


  12 in total

1.  Randomised double blind study of hypotonic oral rehydration solution in diarrhoea.

Authors:  T Rautanen; S Kurki; T Vesikari
Journal:  Arch Dis Child       Date:  1997-03       Impact factor: 3.791

2.  Management of acute diarrhoea with low osmolarity oral rehydration solutions and Lactobacillus strain GG.

Authors:  T Rautanen; E Isolauri; E Salo; T Vesikari
Journal:  Arch Dis Child       Date:  1998-08       Impact factor: 3.791

3.  Double blind, randomised controlled clinical trial of hypo-osmolar oral rehydration salt solution in dehydrating acute diarrhoea in severely malnourished (marasmic) children.

Authors:  P Dutta; U Mitra; B Manna; S K Niyogi; K Roy; C Mondal; S K Bhattacharya
Journal:  Arch Dis Child       Date:  2001-03       Impact factor: 3.791

Review 4.  An evidence and consensus based guideline for acute diarrhoea management.

Authors:  K Armon; T Stephenson; R MacFaul; P Eccleston; U Werneke
Journal:  Arch Dis Child       Date:  2001-08       Impact factor: 3.791

5.  Acute gastroenteritis in Europe and the use of oral rehydration therapy.

Authors:  J H Hoekstra
Journal:  Clin Investig       Date:  1994-02

6.  Efficacy of standard glucose-based and reduced-osmolarity maltodextrin-based oral rehydration solutions: effect of sugar malabsorption.

Authors:  M el-Mougi; A Hendawi; H Koura; E Hegazi; O Fontaine; N F Pierce
Journal:  Bull World Health Organ       Date:  1996       Impact factor: 9.408

7.  Effect of reducing sodium or glucose concentration in a hypo-osmolar ORS (oral rehydration salts) on absorption efficiency: marker perfusion study in rat jejunum.

Authors:  Manoj K Chakrabarti; Kazi M Haque; Manilal Chakrabarty; Dilip Mahalanabis
Journal:  Dig Dis Sci       Date:  2005-02       Impact factor: 3.199

8.  Absorption of a hypotonic oral rehydration solution in a human model of cholera.

Authors:  J B Hunt; A V Thillainayagam; S Carnaby; P D Fairclough; M L Clark; M J Farthing
Journal:  Gut       Date:  1994-02       Impact factor: 23.059

9.  Comparison of three oral rehydration strategies in the treatment of acute diarrhea in a tropical country.

Authors:  Salvatore Pignatelli; Salvatore Musumeci
Journal:  Curr Ther Res Clin Exp       Date:  2003-03

10.  Randomised double blind trial of hypotonic oral rehydration solutions with and without citrate.

Authors:  T Rautanen; E Salo; M Verkasalo; T Vesikari
Journal:  Arch Dis Child       Date:  1994-01       Impact factor: 3.791
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