Literature DB >> 844531

Comparison of the inhibition of avian and mammalian bone alkaline phosphatases by levamisole and compound R8231.

J J Reynolds, G W Dew.   

Abstract

Alkaline phosphatases from mammalian bone are inhibited much more than chick bone alkaline phsophatase by levamisole and compound R8231. Doses of R8231 (10(-4) to 10(-5) M) that almost completely inhibit mammalian alkaline phosphatases do not inhibit the growth of embryonic rat femurs in vitro. R8231 should be an excellent biological probe for the function of alkaline phosphatase in bone metabolism.

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Year:  1977        PMID： 844531     DOI： 10.1007/BF02124036

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  Inhibition studies of alkaline phosphatase in hard tissue-forming cells.

Authors:  A Linde; B C Magnusson
Journal:  J Histochem Cytochem       Date:  1975-05       Impact factor: 2.479

2.  The inhibition of alkaline phosphatase by L-p-bromotetramisole.

Authors:  M Borgers; F Thoné
Journal:  Histochemistry       Date:  1975-08-28

3.  Kinetics and inhibition of alkaline phosphatases from canine tissues.

Authors:  H Van Belle
Journal:  Biochim Biophys Acta       Date:  1972-11-10

4.  Pyrophosphate stimulation of calcium uptake into cultured embryonic bones. Fine structure of matrix vesicles and their role in calcification.

Authors:  H C Anderson; J J Reynolds
Journal:  Dev Biol       Date:  1973-10       Impact factor: 3.582

5.  The pyrophosphatase and (Ca2+-Mg2+)-ATPase activity of purified calf bone alkaline phosphatase.

Authors:  R Felix; H Fleisch
Journal:  Biochim Biophys Acta       Date:  1974-05-20

6.  The cytochemical application of new potent inhibitors of alkaline phosphatases.

Authors:  M Borgers
Journal:  J Histochem Cytochem       Date:  1973-09       Impact factor: 2.479

7.  Studies on matrix vesicles isolated from chick epiphyseal cartilage. Association of pyrophosphatase and ATPase activities with alkaline phosphatase.

Authors:  R J Majeska; R E Wuthier
Journal:  Biochim Biophys Acta       Date:  1975-05-23

8.  Tetramisole (R 8299), a new, potent broad spectrum anthelmintic.

Authors:  D Thienpont; O F Vanparijs; A H Raeymaekers; J Vandenberk; J A Demoen; F T Allewijn; R P Marsboom; C J Niemegeers; K H Schellekens; P A Janssen
Journal:  Nature       Date:  1966-03-12       Impact factor: 49.962

9.  Inhibition of the alkaline phosphatase of equine, bovine and rat neutrophilic leukocytes with levamisole at low concentrations.

Authors:  H Jalanka; L A Lindberg
Journal:  Histochemistry       Date:  1975-12-19
  9 in total
  2 in total

1.  Kinetics of beta-glycerophosphate-induced endochondral mineralization in vitro. Calcium accumulation, alkaline phosphatase activity, and effects of levamisole.

Authors:  B Zimmermann; H C Wachtel; J Vormann
Journal:  Calcif Tissue Int       Date:  1992-07       Impact factor: 4.333

2.  Levamisole inhibits mineral mobilisation, lactate production and lysosomal enzyme release from cultured bones.

Authors:  U Lerner; G T Gustafson
Journal:  Experientia       Date:  1979-04-15
  2 in total

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