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Literature DB >> 171243

The inhibition of alkaline phosphatase by L-p-bromotetramisole.

Abstract

A levamisole analogue, the L-p-bromotetramisole is introduced as a potent inhibitor of non-specific alkaline phosphatase. Complete inhibition is achieved cytochemically at a concentration of 0.1 mM in various rat tissues except the intestine, which is not affected. The D-p-bromotetramisole does not influence the alkaline phosphatase activities. Since no effect of the inhibitor is seen on the activities of specific phosphatases, this drug is recommended also as an additive for specific phosphatase media in order to yield the specific activity only.

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Year: 1975 PMID： 171243 DOI： 10.1007/bf00491496

Source DB: PubMed Journal: Histochemistry ISSN： 0301-5564

7 in total

1. The development of alkaline phosphatase in trichinous muscle.

Authors: M Borgers; S De Nollin; F Thoné
Journal: Histochemistry Date: 1975-06-05

2. Kinetics and inhibition of alkaline phosphatases from canine tissues.

Authors: H Van Belle
Journal: Biochim Biophys Acta Date: 1972-11-10

3. Characterization of the B-cell and T-cell regions of human lymphatic tissue through enzyme histochemical demonstration of ATPase and 5'-nucleotidase activities.

Authors: H K Müller-Hermelink
Journal: Virchows Arch B Cell Pathol Date: 1974

4. Alkaline phosphatase, 5'-nucleotidase and ATPase activity in the molar region of the mouse.

Authors: B C Magnusson; A Linde
Journal: Histochemistry Date: 1974

5. The cytochemical application of new potent inhibitors of alkaline phosphatases.

Authors: M Borgers
Journal: J Histochem Cytochem Date: 1973-09 Impact factor: 2.479

6. Problems of specificity in the use of a strontium capture technique for the cytochemical localization of ouabain-sensitive, potassium-dependent phosphatase in mammalian renal tubules.

Authors: J A Firth
Journal: J Histochem Cytochem Date: 1974-12 Impact factor: 2.479

7. Studies on 5'-nucleotidase histochemistry. I. 5'-Nucleotidase activity in the developing esophagus of the mouse.

Authors: K Klaushofer; P Böck; M M Müller
Journal: Histochemistry Date: 1974-03-27

7 in total

40 in total

1. Species differences in adenosine metabolic sites in the heart.

Authors: M Borgers; F Thoné
Journal: Histochem J Date: 1992-07

2. Diurnal variation in 5'-nucleotidase activity in rat liver. A quantitative histochemical study.

Authors: W M Frederiks; F Marx; K S Bosch; C J Van Noorden
Journal: Histochemistry Date: 1987

3. Demonstration of glucose-6-phosphatase and peroxisomal catalase activity by ultrastructural cytochemistry in oval cells from livers of carcinogen-treated rats.

Authors: F Plenat; L Braun; N Fausto
Journal: Am J Pathol Date: 1988-01 Impact factor: 4.307

10. Ecto-ATPase/phosphatase activity in the olfactory sensilla of the spiny lobster, Panulirus argus: localization and characterization.

Authors: R A Gleeson; H G Trapido-Rosenthal; L M McDowell; H C Aldrich; W E Carr
Journal: Cell Tissue Res Date: 1992-09 Impact factor: 5.249

The inhibition of alkaline phosphatase by L-p-bromotetramisole.

1. The development of alkaline phosphatase in trichinous muscle.

2. Kinetics and inhibition of alkaline phosphatases from canine tissues.

3. Characterization of the B-cell and T-cell regions of human lymphatic tissue through enzyme histochemical demonstration of ATPase and 5'-nucleotidase activities.

4. Alkaline phosphatase, 5'-nucleotidase and ATPase activity in the molar region of the mouse.

5. The cytochemical application of new potent inhibitors of alkaline phosphatases.

6. Problems of specificity in the use of a strontium capture technique for the cytochemical localization of ouabain-sensitive, potassium-dependent phosphatase in mammalian renal tubules.

7. Studies on 5'-nucleotidase histochemistry. I. 5'-Nucleotidase activity in the developing esophagus of the mouse.

1. Species differences in adenosine metabolic sites in the heart.

2. Diurnal variation in 5'-nucleotidase activity in rat liver. A quantitative histochemical study.

3. Demonstration of glucose-6-phosphatase and peroxisomal catalase activity by ultrastructural cytochemistry in oval cells from livers of carcinogen-treated rats.

4. Cytochemical studies on the localization of 5'-nucleotidase in the acinar cells of the rat salivary glands.

5. Enzyme studies on TPPase-reactive cytoplasmic structures observed in early meiotic prophase I of the hamster oocyte.

6. Increase in alkaline phosphatase activity in calvaria cells cultured with diphosphonates.

7. The effect of zinc on alkaline phosphatase activity in rheumatoid synovial tissue.

8. Alkaline phosphatase activity in human polymorphonuclear leukocytes.

9. Pitfalls in the light microscopical detection of NADH oxidase.

10. Ecto-ATPase/phosphatase activity in the olfactory sensilla of the spiny lobster, Panulirus argus: localization and characterization.