Literature DB >> 8444

Charge transfer mediated by nigericin in black lipid membranes.

M Toro, C Gómez-Lojero, M Montal, S Estrada-O.   

Abstract

Nigericin, in the concentration range (10(-6) M or higher) at which it uncouples intact mitochondria, was found to increase the conductance of black lipid membranes (BLM) by several orders of magnitude. The dependence of the membrane conductance on pH and K+ concentration suggests a mechanism for the transfer of charge mediated by this ionophore based on a mobile dimer with both nigericin molecules protonated and complexed with one K+. This charged complex accounts for the uncoupling effect observed in intact mitochondria.

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Year:  1976        PMID： 8444     DOI： 10.1007/BF01559387

Source DB:  PubMed          Journal:  J Bioenerg        ISSN： 0449-5705


  29 in total

1.  Reconstitution of cell membrane structure in vitro and its transformation into an excitable system.

Authors:  P MUELLER; D O RUDIN; H T TIEN; W C WESCOTT
Journal:  Nature       Date:  1962-06-09       Impact factor: 49.962

2.  Ion transport and energy conservation in submitochondrial particles.

Authors:  M Montal; B Chance; C P Lee
Journal:  J Membr Biol       Date:  1970-12       Impact factor: 1.843

3.  The effect of uncouplers of oxidative phosphorylation on lipid bilayer membranes: Carbonylcyanidem-chlorophenylhydrazone.

Authors:  O H Leblanc
Journal:  J Membr Biol       Date:  1971-12       Impact factor: 1.843

4.  Lipid-polypeptide interactions in bilayer lipid membranes.

Authors:  M Montal
Journal:  J Membr Biol       Date:  1972-12       Impact factor: 1.843

5.  Potassium Ion-dependent hydrolysis of adenosine triphosphate induced by nigericin in mitochondria.

Authors:  S Estrada-O; S N Graven; H A Lardy
Journal:  J Biol Chem       Date:  1967-06-25       Impact factor: 5.157

6.  Physical properties of biological membranes determined by the fluorescence of the calcium ionophore A23187.

Authors:  G D Case; J M Vanderkooi; A Scarpa
Journal:  Arch Biochem Biophys       Date:  1974-05       Impact factor: 4.013

7.  The mechanism of action of DNP on phospholipid bilayer membranes.

Authors:  S McLaughlin
Journal:  J Membr Biol       Date:  1972       Impact factor: 1.843

8.  Release of respiratory control in particles from Micrococcus denitrificans by ion-translocating antibiotics.

Authors:  P John; W A Hamilton
Journal:  Eur J Biochem       Date:  1971-12-10

9.  K+ -dependent uncoupling of photophosphorylation by nigericin.

Authors:  N Shavit; A San Pietro
Journal:  Biochem Biophys Res Commun       Date:  1967-07-21       Impact factor: 3.575

10.  The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability.

Authors:  P J Henderson; J D McGivan; J B Chappell
Journal:  Biochem J       Date:  1969-02       Impact factor: 3.857
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  7 in total

1.  Effects of osmolality and calcium on renin release from superfused rat glomeruli treated with nigericin or monensin.

Authors:  O Skøtt
Journal:  Pflugers Arch       Date:  1988-10       Impact factor: 3.657

2.  Requirement for membrane potential in injection of phage T4 DNA.

Authors:  B Labedan; E B Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

3.  Transport of potassium ions across planar lipid membranes by the antibiotic, grisorixin: I. The equilibrium state and self-diffusion K+ fluxes.

Authors:  G Amblard; R Sandeaux; J Sandeaux; C Gavach
Journal:  J Membr Biol       Date:  1985       Impact factor: 1.843

4.  Formation of ion-translocating oligomers by nigericin.

Authors:  M Toro; E Arzt; J Cerbón; G Alegría; R Alva; Y Meas; S Estrada
Journal:  J Membr Biol       Date:  1987       Impact factor: 1.843

5.  Nigericin forms highly stable complexes with lithium and cesium.

Authors:  R Alva; J A Lugo; E Arzt; J Cerbón; B E Rivera; M Toro; S Estrada
Journal:  J Bioenerg Biomembr       Date:  1992-02       Impact factor: 2.945

6.  The use of valinomycin, nigericin and trichlorocarbanilide in control of the protonmotive force in Escherichia coli cells.

Authors:  S Ahmed; I R Booth
Journal:  Biochem J       Date:  1983-04-15       Impact factor: 3.857

7.  Identification of novel biomarkers and candidate small molecule drugs in non-small-cell lung cancer by integrated microarray analysis.

Authors:  Qiong Wu; Bo Zhang; Yidan Sun; Ran Xu; Xinyi Hu; Shiqi Ren; Qianqian Ma; Chen Chen; Jian Shu; Fuwei Qi; Ting He; Wei Wang; Ziheng Wang
Journal:  Onco Targets Ther       Date:  2019-05-13       Impact factor: 4.147
  7 in total

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