Literature DB >> 5774477

The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability.

P J Henderson, J D McGivan, J B Chappell.   

Abstract

1. The action of the antibiotics enniatin A, valinomycin, the actin homologues, gramicidin, nigericin and dianemycin on mitochondria, erythrocytes and smectic mesophases of lecithin-dicetyl hydrogen phosphate was studied. 2. These antibiotics induced permeability to alkali-metal cations on all three membrane systems. 3. The ion specificity on each membrane system was the same. 4. Enniatin A, valinomycin and the actins did not induce permeability to protons, whereas nigericin and dianemycin rendered all three membrane systems freely permeable to protons. 5. Several differences were noted between permeability induced by nigericin and that induced by gramicidin. 6. The action of all these antibiotics on mitochondrial respiration could be accounted for by changes in passive ion permeability of the mitochondrial membrane similar to those induced in erythrocytes and phospholipid membranes, if it is assumed that a membrane potential is present in respiring mitochondria.

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Year:  1969        PMID: 5774477      PMCID: PMC1187573          DOI: 10.1042/bj1110521

Source DB:  PubMed          Journal:  Biochem J        ISSN: 0264-6021            Impact factor:   3.857


  27 in total

1.  Antibiotics as tools for metabolic studies. I. A survey of toxic antibiotics in respiratory, phosphorylative and glycolytic systems.

Authors:  H A LARDY; D JOHNSON; W C McMURRAY
Journal:  Arch Biochem Biophys       Date:  1958-12       Impact factor: 4.013

2.  Antibiotic-mediated transport of alkali ions across lipid barriers.

Authors:  B C Pressman; E J Harris; W S Jagger; J H Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1967-11       Impact factor: 11.205

Review 3.  Translocations through natural membranes.

Authors:  P Mitchell
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1967

4.  Effect of transport-inducing antibiotics and other agents on potassium flux in mitochondria.

Authors:  E J Harris; G Catlin; B C Pressman
Journal:  Biochemistry       Date:  1967-05       Impact factor: 3.162

5.  The light-induced, reversible pH change in chromatophores from Rhodospirillum rubrum.

Authors:  L V von Stedingk; H Baltscheffsky
Journal:  Arch Biochem Biophys       Date:  1966-11       Impact factor: 4.013

6.  K+ -dependent uncoupling of photophosphorylation by nigericin.

Authors:  N Shavit; A San Pietro
Journal:  Biochem Biophys Res Commun       Date:  1967-07-21       Impact factor: 3.575

7.  Development of K+-Na+ discrimination in experimental bimolecular lipid membranes by macrocyclic antibiotics.

Authors:  P Mueller; D O Rudin
Journal:  Biochem Biophys Res Commun       Date:  1967-02-21       Impact factor: 3.575

8.  Specific induction and inhibition of cation and anion transport in mitochondria.

Authors:  H A Lardy; S N Graven; S Estrada
Journal:  Fed Proc       Date:  1967-09

9.  The effect of dinitrophenol on the permeability of the mitochondrial membrane.

Authors:  E Carafoli; C S Rossi
Journal:  Biochem Biophys Res Commun       Date:  1967-10-26       Impact factor: 3.575

10.  Obligate cation exchanges in red cells.

Authors:  E J Harris; B C Pressman
Journal:  Nature       Date:  1967-12-02       Impact factor: 49.962

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  102 in total

1.  The uptake and extrusion of monovalent cations by isolated heart mitochondria.

Authors:  G P Brierley
Journal:  Mol Cell Biochem       Date:  1976-01-31       Impact factor: 3.396

Review 2.  Conformational changes in cytochrome aa3 and ATP synthetase of the mitochondrial membrane and their role in mitochondrial energy transduction.

Authors:  M K Wikström; H T Saari
Journal:  Mol Cell Biochem       Date:  1976-03-26       Impact factor: 3.396

3.  Biochemical studies of pigments from a pathogenic fungus Microsporum cookei. V. Evidence for the transmembrane permeability of xanthomegnin across phospholipid bilayer membranes.

Authors:  K Kawai; T Akita; Y Nozawa
Journal:  Experientia       Date:  1978-08-15

4.  Generation of plasma membrane potential by the Na+-pump coupled to proton extrusion.

Authors:  C L Bashford; C A Pasternak
Journal:  Eur Biophys J       Date:  1985       Impact factor: 1.733

5.  The Relation between Photophosphorylation and Delayed Light Emission in Chloroplasts.

Authors:  J Neumann; J Barber; P Gregory
Journal:  Plant Physiol       Date:  1973-06       Impact factor: 8.340

6.  The relation of the 515 nanometers absorbance change to adenosine triphosphate formation in chloroplasts and digitonin subchloroplast particles.

Authors:  J Neumann; B Ke; R A Dilley
Journal:  Plant Physiol       Date:  1970-07       Impact factor: 8.340

7.  The intracellular localization of enzymes in white-adipose-tissue fat-cells and permeability properties of fat-cell mitochondria. Transfer of acetyl units and reducing power between mitochondria and cytoplasm.

Authors:  B R Martin; R M Denton
Journal:  Biochem J       Date:  1970-05       Impact factor: 3.857

8.  Real-time attack of LL-37 on single Bacillus subtilis cells.

Authors:  Kenneth J Barns; James C Weisshaar
Journal:  Biochim Biophys Acta       Date:  2013-02-26

9.  Chloride uptake by brush border membrane vesicles isolated from rabbit renal cortex. Coupling to proton gradients and K+ diffusion potentials.

Authors:  D G Warnock; V J Yee
Journal:  J Clin Invest       Date:  1981-01       Impact factor: 14.808

10.  The inhibition of mitochondrial dicarboxylate transport by inorganic phosphate, some phosphate esters and some phosphonate compounds.

Authors:  R N Johnson; J B Chappell
Journal:  Biochem J       Date:  1974-02       Impact factor: 3.857

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