Literature DB >> 8443792

Diethylstilbestrol liver carcinogenicity and modification of DNA in rats.

G M Williams1, M Iatropoulos, R Cheung, L Radi, C X Wang.   

Abstract

Administration of diethylstilbestrol to female Sprague-Dawley rats at 10 mg/kg body weight daily by gavage for 1 year induced liver adenomas and carcinomas and pituitary adenomas. Using the 32P-postlabeling assay for DNA alterations, at 24 h after administration of a single dose of 100 mg/kg, modified bases were found.

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Year:  1993        PMID： 8443792     DOI： 10.1016/0304-3835(93)90146-z

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  4 in total

1.  Transplacental arsenic carcinogenesis in mice.

Authors:  Michael P Waalkes; Jie Liu; Bhalchandra A Diwan
Journal:  Toxicol Appl Pharmacol       Date:  2007-01-12       Impact factor: 4.219

2.  Comparison of DNA reactivity of the polyphenylethylene hormonal agents diethylstilbestrol, tamoxifen and toremifene in rat and hamster liver.

Authors:  F Montandon; G M Williams
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

3.  Comparison of toremifene and tamoxifen in post-menopausal patients with advanced breast cancer: a randomized double-blind, the 'nordic' phase III study.

Authors:  S Pyrhönen; R Valavaara; H Modig; M Pawlicki; T Pienkowski; S Gundersen; J Bauer; G Westman; S Lundgren; G Blanco; O Mella; I Nilsson; T Hietanen; I Hindy; J Vuorinen; A Hajba
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

4.  The need to decide if all estrogens are intrinsically similar.

Authors:  Jonathan G Moggs; John Ashby; Helen Tinwell; Fei Ling Lim; David J Moore; Ian Kimber; George Orphanides
Journal:  Environ Health Perspect       Date:  2004-08       Impact factor: 9.031
  4 in total

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