Literature DB >> 8440369

Growth response to 4-hydroxy-L-threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis.

C Drewke1, C Notheis, U Hansen, E Leistner, T Hemscheidt, R E Hill, I D Spenser.   

Abstract

Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B6) showed a growth response to 4-hydroxy-L-threonine. This observation constitutes the first direct evidence in support of the view that 4-hydroxy-L-threonine is implicated in the biosynthesis of vitamin B6. 1-Aminopropan-2,3-diol, the decarboxylation product of 4-hydroxy-L-threonine, does not support the growth of these mutants. Deuterium from deuterium-labelled 1-aminopropan-2,3-diol was not incorporated into pyridoxol.

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Year:  1993        PMID： 8440369     DOI： 10.1016/0014-5793(93)80005-f

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12.

Authors:  T K Man; G Zhao; M E Winkler
Journal:  J Bacteriol       Date:  1996-04       Impact factor: 3.490

2.  Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12.

Authors:  Y Yang; G Zhao; T K Man; M E Winkler
Journal:  J Bacteriol       Date:  1998-08       Impact factor: 3.490

3.  Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network.

Authors:  Juhan Kim; Shelley D Copley
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-14       Impact factor: 11.205

4.  An Escherichia coli K-12 tktA tktB mutant deficient in transketolase activity requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth.

Authors:  G Zhao; M E Winkler
Journal:  J Bacteriol       Date:  1994-10       Impact factor: 3.490

5.  Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis.

Authors:  Susan Wagner; Anne Bernhardt; Jan Erik Leuendorf; Christel Drewke; Anna Lytovchenko; Nader Mujahed; Cristian Gurgui; Wolf B Frommer; Eckhard Leistner; Alisdair R Fernie; Hanjo Hellmann
Journal:  Plant Cell       Date:  2006-06-09       Impact factor: 11.277

6.  Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12.

Authors:  Y Yang; H C Tsui; T K Man; M E Winkler
Journal:  J Bacteriol       Date:  1998-04       Impact factor: 3.490

7.  Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis.

Authors:  G Zhao; A J Pease; N Bharani; M E Winkler
Journal:  J Bacteriol       Date:  1995-05       Impact factor: 3.490

8.  Kinetic limitation and cellular amount of pyridoxine (pyridoxamine) 5'-phosphate oxidase of Escherichia coli K-12.

Authors:  G Zhao; M E Winkler
Journal:  J Bacteriol       Date:  1995-02       Impact factor: 3.490

9.  Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis.

Authors:  Juhan Kim; Jamie P Kershner; Yehor Novikov; Richard K Shoemaker; Shelley D Copley
Journal:  Mol Syst Biol       Date:  2010-11-30       Impact factor: 11.429

Review 10.  Vitamin B6: a long known compound of surprising complexity.

Authors:  Sutton Mooney; Jan-Erik Leuendorf; Christopher Hendrickson; Hanjo Hellmann
Journal:  Molecules       Date:  2009-01-12       Impact factor: 4.411
  10 in total

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