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Literature DB >> 843832

Antiribonucleoprotein antibodies in connective tissue diseases: estimation by counterimmunoelectrophoresis.

B Bresnihan, C Bunn, M L Snaith, G R Hughes.

Abstract

One hundred and seventy-two patients with various connective tissue diseases were investigated for the presence of serum antibodies to extractable nuclear antigen (ENA) and its major components, ribonucleo-protein (RNP) and Sm antigen. The counter-immunoelectrophoresis assay allowed independent detection and measurement of antibodies to the different components. All 13 patients with mixed connective tissue disease (MCTD) had anti-RNP antibody in high titres, 16% of patients with systemic lupus erythematosus (SLE) had low titres, and none of the patients with scleroderma had anti-RNP antibody. MCTD seems to be more benign than either SLE or scleroderma. The counterimmunoelectrophoresis assay is a simple and sensitive technique for confirming the diagnosis.

Entities: Disease Species

Mesh：

Substances：

Year: 1977 PMID： 843832 PMCID： PMC1605334 DOI： 10.1136/bmj.1.6061.610

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

5 in total

1. Profiles of antinuclear antibodies in systemic rheumatic diseases.

Authors: D D Notman; N Kurata; E M Tan
Journal: Ann Intern Med Date: 1975-10 Impact factor: 25.391

2. Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis.

Authors: N Kurata; E M Tan
Journal: Arthritis Rheum Date: 1976 May-Jun

3. Ribonucleoprotein antibodies: frequency and clinical significance in systemic lupus erythematosus, scleroderma, and mixed connective tissue disease.

Authors: M D Parker
Journal: J Lab Clin Med Date: 1973-11

4. Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA).

Authors: G C Sharp; W S Irvin; E M Tan; R G Gould; H R Holman
Journal: Am J Med Date: 1972-02 Impact factor: 4.965

5. Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus.

Authors: E M Tan; H G Kunkel
Journal: J Immunol Date: 1966-03 Impact factor: 5.422

5 in total

9 in total

1. Antibodies to extractable nuclear antigens. Has technological drift affected clinical interpretation?

Authors: R J Lock; D J Unsworth
Journal: J Clin Pathol Date: 2001-03 Impact factor: 3.411

2. Polymyositis and acute onset systemic sclerosis in a patient with primary biliary cirrhosis: a clinical syndrome similar to the mixed connective tissue disease.

Authors: O Epstein; A K Burroughs; S Sherlock
Journal: J R Soc Med Date: 1981-06 Impact factor: 5.344

Antiribonucleoprotein antibodies in connective tissue diseases: estimation by counterimmunoelectrophoresis.

1. Profiles of antinuclear antibodies in systemic rheumatic diseases.

2. Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis.

3. Ribonucleoprotein antibodies: frequency and clinical significance in systemic lupus erythematosus, scleroderma, and mixed connective tissue disease.

4. Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA).

5. Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus.

1. Antibodies to extractable nuclear antigens. Has technological drift affected clinical interpretation?

2. Polymyositis and acute onset systemic sclerosis in a patient with primary biliary cirrhosis: a clinical syndrome similar to the mixed connective tissue disease.

3. Rheumatic disease in Jamaica.

4. Prospective analysis of antiribonucleoprotein antibodies in systemic lupus erythematosus.

5. Systemic lupus erythematosus. A prospective analysis.

6. Hashimoto's thyroiditis and polyarthritis: a possible subset of seronegative polyarthritis.

7. Clinical profiles of patients with antibodies to nuclear ribonucleoprotein.

8. Is MCTD a distinct entity? Comparison of clinical and laboratory findings in MCTD, SLE, PSS, and RA patients.

9. Hydralazine, antinuclear antibodies, and the lupus syndrome.