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Literature DB >> 596947

Prospective analysis of antiribonucleoprotein antibodies in systemic lupus erythematosus.

Abstract

A prospective analysis of 50 successive patients with systemic lupus erythematosus, seen over a 4-year period, has been completed. 336 sera were examined for the presence of antibody to ribonucleoprotein using a counterimmunoelectrophoresis assay. Antibody was present in the sera of 16% of patients and was detectable in about the same titre throughout the course of the disease. The presence of the antibody did not appear to identify a subgroup of lupus patients with individual clinical characteristics.

Entities: Disease Species

Mesh：

Substances：

Year: 1977 PMID： 596947 PMCID： PMC1000162 DOI： 10.1136/ard.36.6.557

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

8 in total

1. Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis.

Authors: N Kurata; E M Tan
Journal: Arthritis Rheum Date: 1976 May-Jun

2. Deoxyribonucleic acid antibody: a method to detect its primary interaction with deoxyribonucleic acid.

Authors: R T Wold; F E Young; E M Tan; R S Farr
Journal: Science Date: 1968-08-23 Impact factor: 47.728

3. Correlation of a precipitin reaction to an RNAprotein antigen and a low prevalence of nephritis in patients with systemic lupus erythematosus.

Authors: M Reichlin; M Mattioli
Journal: N Engl J Med Date: 1972-04-27 Impact factor: 91.245

4. Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA).

Authors: G C Sharp; W S Irvin; E M Tan; R G Gould; H R Holman
Journal: Am J Med Date: 1972-02 Impact factor: 4.965

5. Specific concentration of polynucleotide immune complexes in the cryoprecipitates of patients with systemic lupus erythematosus.

Authors: J B Winfield; D Koffler; H G Kunkel
Journal: J Clin Invest Date: 1975-09 Impact factor: 14.808

6. Characteristics of patients with serum antibodies to extractable nuclear antigens.

Authors: J H Leibfarth; R H Persellin
Journal: Arthritis Rheum Date: 1976 Sep-Oct

7. Association of autoantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy.

Authors: G C Sharp; W S Irvin; R L LaRoque; C Velez; V Daly; A D Kaiser; H R Holman
Journal: J Clin Invest Date: 1971-02 Impact factor: 14.808

8. Antiribonucleoprotein antibodies in connective tissue diseases: estimation by counterimmunoelectrophoresis.

Authors: B Bresnihan; C Bunn; M L Snaith; G R Hughes
Journal: Br Med J Date: 1977-03-05

8 in total

6 in total

Prospective analysis of antiribonucleoprotein antibodies in systemic lupus erythematosus.

1. Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis.

2. Deoxyribonucleic acid antibody: a method to detect its primary interaction with deoxyribonucleic acid.

3. Correlation of a precipitin reaction to an RNAprotein antigen and a low prevalence of nephritis in patients with systemic lupus erythematosus.

4. Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA).

5. Specific concentration of polynucleotide immune complexes in the cryoprecipitates of patients with systemic lupus erythematosus.

6. Characteristics of patients with serum antibodies to extractable nuclear antigens.

7. Association of autoantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy.

8. Antiribonucleoprotein antibodies in connective tissue diseases: estimation by counterimmunoelectrophoresis.

Review 1. Systemic lupus erythematosus clinical issues.

2. Systemic lupus erythematosus. A prospective analysis.

3. Antibodies to distinct polypeptides of RNA polymerase I in sera from patients with rheumatic autoimmune disease.

4. Systemic lupus erythematosus in North Indian Asians. A prospective analysis of clinical and immunological features.

5. In vivo anti-nuclear antibodies in epithelial biopsies in SLE and other connective tissue diseases.

6. Analysis of speckled fluorescent antinuclear antibody test antisera using electrofocused nuclear antigens.