Literature DB >> 843831

Quinine-induced agranulocytosis: toxic effect of quinine bisulphate on bone marrow cultures in vitro.

R Sutherland, P C Vincent, E Raik, K Burgess.   

Abstract

In a case of quinine-induced agranulocytosis marrow culture studies confirmed the inhibitory effect on the patient's cells of equivalent therapeutic plasma concentrations of quinine. Similar concentrations had no effect on normal marrow cells. Quinidine, the stereoisomer of quinine, had no effect on either cells from the patient or normal cells. The results encourage the use of in-vitro bone marrow cultures for identifying drugs responsible for agranulocytosis.

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Year:  1977        PMID： 843831      PMCID： PMC1605320          DOI： 10.1136/bmj.1.6061.605

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  3 in total

1.  Effect of chloramphenicol and thiamphenicol on the in vitro colony-forming cell.

Authors:  R J Ratzan; M A Moore; A A Yunis
Journal:  Blood       Date:  1974-03       Impact factor: 22.113

2.  The effects of drugs that cause neutropenia upon colony formation by bone marrow cells in semi-solid agar.

Authors:  A Howell; S Chinn; T M Andrews; R W Watts
Journal:  Clin Sci Mol Med       Date:  1974-05

3.  Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro.

Authors:  D E Lind; J A Levi; P C Vincent
Journal:  Br Med J       Date:  1973-02-24
  3 in total
  8 in total

1.  Quinine allergy causing acute severe systemic illness: report of 4 patients manifesting multiple hematologic, renal, and hepatic abnormalities.

Authors:  Mark A Howard; Andrea B Hibbard; Deirdra R Terrell; Patrick J Medina; Sara K Vesely; James N George
Journal:  Proc (Bayl Univ Med Cent)       Date:  2003-01

Review 2.  Drug-induced agranulocytosis.

Authors:  H Heimpel
Journal:  Med Toxicol Adverse Drug Exp       Date:  1988 Nov-Dec

3.  Relevance of in vitro studies of drug-induced agranulocytosis. Report of 14 cases.

Authors:  D M Parent-Massin; L Sensébé; M C Léglise; G Guern; C Berthou; C Riché; J F Abgrall
Journal:  Drug Saf       Date:  1993-12       Impact factor: 5.606

Review 4.  In vitro evidence of drug action in aplastic anemia.

Authors:  P C Vincent
Journal:  Blut       Date:  1984-07

5.  Laboratory studies in drug-induced pancytopenia.

Authors: 
Journal:  Br Med J       Date:  1980-02-16

6.  Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms.

Authors:  P C Vincent
Journal:  Drugs       Date:  1986-01       Impact factor: 9.546

7.  Agranulocytosis associated with aminoglutethimide: pharmacological and marrow studies.

Authors:  A L Harris; G Hughes; A J Barrett; S Abusrewil; M Dowsett; I E Smith
Journal:  Br J Cancer       Date:  1986-07       Impact factor: 7.640

8.  Pediatric drug safety signal detection: a new drug-event reference set for performance testing of data-mining methods and systems.

Authors:  Osemeke U Osokogu; Federica Fregonese; Carmen Ferrajolo; Katia Verhamme; Sandra de Bie; Geert 't Jong; Mariana Catapano; Daniel Weibel; Florentia Kaguelidou; Wichor M Bramer; Yingfen Hsia; Ian C K Wong; Madlen Gazarian; Jan Bonhoeffer; Miriam Sturkenboom
Journal:  Drug Saf       Date:  2015-02       Impact factor: 5.606
  8 in total

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